From: Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study
HLI | Colon cancer | Rectal cancer | Colorectal cancer | |||
---|---|---|---|---|---|---|
Cases, number | HRb(95% CI) | Cases, number | HRb(95% CI) | Cases, number | HRb(95% CI) | |
All participants | ||||||
0 or 1 | 216 | 1 (Reference) | 133 | 1 (Reference) | 349 | 1 (Reference) |
2 | 526 | 0.85 (0.72 to 0.99) | 326 | 0.90 (0.74 to 1.11) | 852 | 0.87 (0.76 to 0.98) |
3 | 816 | 0.78 (0.67 to 0.91) | 459 | 0.80 (0.66 to 0.97) | 1275 | 0.79 (0.70 to 0.89) |
4 | 602 | 0.64 (0.54 to 0.75) | 348 | 0.70 (0.57 to 0.85) | 950 | 0.66 (0.58 to 0.75) |
5 | 209 | 0.61 (0.50 to 0.74) | 124 | 0.68 (0.53 to 0.88) | 333 | 0.63 (0.54 to 0.74) |
P-trend | <0.0001 | <0.0001 | <0.0001 | |||
Per one point increase | 0.87 (0.84 to 0.91) | 0.90 (0.85 to 0.94) | 0.88 (0.86 to 0.92) | |||
P-valuec | <0.0001 | <0.0001 | <0.0001 | |||
Men | ||||||
0 or 1 | 135 | 1 (Reference) | 94 | 1 (Reference) | 229 | 1 (Reference) |
2 | 266 | 0.80 (0.65 to 0.98) | 196 | 0.87 (0.67 to 1.10) | 462 | 0.83 (0.71 to 0.97) |
3 | 330 | 0.70 (0.57 to 0.85) | 236 | 0.75 (0.59 to 0.95) | 566 | 0.72 (0.62 to 0.84) |
4 | 215 | 0.59 (0.46 to 0.73) | 160 | 0.66 (0.51 to 0.85) | 375 | 0.62 (0.52 to 0.73) |
5 | 83 | 0.61 (0.46 to 0.81) | 42 | 0.47 (0.32 to 0.68) | 125 | 0.56 (0.44 to 0.69) |
P-trend | <0.0001 | <0.0001 | <0.0001 | |||
Per one point increase | 0.86 (0.82 to 0.91) | 0.86 (0.80 to 0.91) | 0.87 (0.83 to 0.90) | |||
P-valuec | <0.0001 | <0.0001 | <0.0001 | |||
Women | ||||||
0 or 1 | 81 | 1 (Reference) | 39 | 1 (Reference) | 120 | 1 (Reference) |
2 | 260 | 0.93 (0.73 to 1.20) | 130 | 1.03 (0.72 to 1.48) | 390 | 0.97 (0.78 to 1.18) |
3 | 486 | 0.91 (0.71 to 1.14) | 223 | 0.96 (0.68 to 1.36) | 709 | 0.92 (0.76 to 1.12) |
4 | 387 | 0.72 (0.56 to 0.92) | 188 | 0.84 (0.59 to 1.19) | 575 | 0.76 (0.62 to 0.93) |
5 | 126 | 0.65 (0.48 to 0.86) | 82 | 1.01 (0.68 to 1.49) | 208 | 0.76 (0.60 to 0.95) |
P-trendc | <0.0001 | 0.35 | <0.0001 | |||
Per one point increase | 0.88 (0.84 to 0.93) | 0.97 (0.99 to 1.04) | 0.91 (0.87 to 0.95) | |||
P-value | <0.0001 | 0.35 | <0.0001 |