From: Candidate gene-environment interactions in breast cancer
Reference | Study | SNPs | ERFs | Cases | Controls | Strongest interaction | Interaction effect size | UnadjustedP |
---|---|---|---|---|---|---|---|---|
Travis et al. [3] | Million women | 12 | 10 | 7,610 | 10,196 | CASP8-rs1045485; alcohol consumptiona | 1.24 | 0.003 |
Milne et al. [4] | BCAC (1) | 12 | 4 | 26,349 | 32,208 | LSP1- rs3817198; parity | 1.05 | 0.002 |
Campa et al. [6] | BPC3 (1) | 17 | 9 | 8,576 | 11,892 | 5p12-rs10941679; use of estrogen only HRT | 1.22 | 0.0072 |
Nickels et al. [5] | BCAC (2) | 23 | 10 | 34,793 | 41,099 | LSP1- rs3817198; parity | 1.06 | 2.4 × 10-6 |
1p11.2-rs11249433; ever parous | 1.16 | 5.3 × 10-5 | ||||||
CASP8-rs17468277; alcohol consumptiona | 1.59 | 3.1 × 10-4 | ||||||
Barrdahl et al. [7] | BPC3 (2) | 39 | 10 | 16,285 | 19,376 | 6q25-rs2046210; alcohol consumptiona | 1.11 | 0.002 |
Schoeps et al. [12] | BCAC | 71,527 | 10 | 34,475 | 34,786 | 21q22.12-rs10483028 and rs2242714; postmenopausal BMI | 0.84 | 3.2 × 10-5 |