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Figure 3 | BMC Medicine

Figure 3

From: In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver

Figure 3

Expression of selected transcripts encoding members of the 1-Carbon cycle (A-I) and DNA methylation enzymes, (J) DNMT1, (K) DNMT3A, (L) DNMT3B, in the human fetal liver and effects of sex and maternal smoking. Real-time PCR was used to measure specific transcript levels as described in the text. Data from individual fetuses (11–16 fetuses per group) are shown, and the horizontal bar represents the mean of the group. Significant differences between groups are indicated by letters in the boxes above each graph. Within each transcript, groups that do not share a letter are significantly (P <0.05) different. NSm, represents control fetuses from non-smoking mothers; Sm, represents smoke-exposed fetuses from mothers who smoked during pregnancy. Fetal sex is denoted by the appropriate symbol.

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