Skip to main content

Table 3 Pooled analysis of secondary outcomes

From: Early goal-directed therapy in the management of severe sepsis or septic shock in adults: a meta-analysis of randomized controlled trials

Outcome

Comparison

Number of studies

MD or RR (95% CI)

P

I 2

Length of ICU stay (d)

EGDT versus control group

6

-0.20 (-1.31 to 0.92)

0.73

75%

Length of in-hospital stay (d)

EGDT versus control group

4

0.42 (-1.02 to 1.86)

0.57

12%

Mechanical ventilation rate

EGDT versus control group

5

0.96 (0.85 to 1.09)

0.53

43%

Mechanical ventilation days (d)

EGDT versus control group

4

-0.91 (-2.34 to 0.52)

0.21

95%

Vasopressor support rate

EGDT versus control group

6

1.03 (0.93 to 1.15)

0.58

69%

Inotropic agents support

EGDT versus control group

5

2.23 (1.06 to 4.67)

0.03

84%

EGDT versus usual care group

4

2.37 (1.02 to 5.51)

0.05

 

EGDT versus early lactate clearance

1

1.60 (0.54 to 4.78)

0.40

88%-

Fluid administration in first 6 h (L)

EGDT versus control group

7

0.88 (-0.17 to 1.93)

0.10

99%

EGDT versus usual care group

5

1.24 (0 to 2.48)

0.05

99%

EGDT versus early lactate clearance

2

0.02 (-0.46 to 0.49)

0.27

17%

Red cell transfusion rate in first 6 h

EGDT versus control group

5

1.76 (1.11 to 2.78)

0.04

76%

EGDT versus usual care group

3

2.26 (1.54 to 3.31)

<0.01

71%

EGDT versus early lactate clearance

2

0.72 (0.27 to 1.94)

0.52

37%

  1. Abbreviations:EGDT early goal-directed therapy, MD mean difference, RR relative risk.