Variable | Placebo (95 % CI) | WJMSCs(95 % CI) | P value |
---|---|---|---|
(number = 55) | (number = 57) | ||
Global LVEF (%) | |||
Baseline | |||
Mean | 51.0±1.1(48.8~53.3) | 52.1±1.0(50.2~54.1) | 0.46 |
4 Months | |||
Mean | 54.2±0.9(52.5~56.1) | 58.5±0.7(57.1~60.0) | 0.0003 |
Difference | 3.2±0.9(1.4~5.0) | 6.4±0.7(4.9~7.9) | 0.008 |
P value (baseline vs.6 months) | 0.0009 | <0.0001 | |
12 Months | |||
Mean | 54.5±0.8(52.8~56.2) | 58.8±0.8(57.3~60.4) | 0.0002 |
Difference | 3.5±0.8(1.9~5.0) | 6.7±0.8(5.1~8.3) | 0.004 |
P value (baseline vs.12 months) | <0.0001 | <0.0001 | |
18 Months | |||
Mean | 54.0±0.8( 52.3~55.7) | 60.0±0.5 (58.9~61.0) | <0.0001 |
Difference | 2.8±1.2(0.4~5.1) | 7.8±0.9(6.0~9.7) | 0.001 |
P value (baseline vs.18 months) | 0.05 | <0.0001 | |
LVFS (%) | |||
Baseline | |||
Mean | 26.6±0.7(25.2~27.9) | 27.3±0.6(26.0~28.6) | 0.42 |
4 Months | |||
Mean | 29.7±0.7(28.3~31.0) | 32.6±0.6(31.4~33.9) | 0.002 |
Difference | 3.1±0.6(1.9~4.3) | 5.3±0.6(4.0~6.6) | 0.01 |
P value (baseline vs.6 months) | <0.0001 | <0.0001 | |
12 Months | |||
Mean | 29.8±0.6(28.5~31.0) | 32.7±0.5(31.7~33.8) | 0.0005 |
Difference | 3.2±0.5(2.1~4.3) | 5.4±0.5(4.3~6.5) | 0.005 |
P value (baseline vs.12 months) | <0.0001 | <0.0001 | |
18 Months | |||
Mean | 28.6±0.6(20.8~35.6) | 33.6±0.5(27.3~39.1) | <0.0001 |
Difference | 2.1±0.8(−8.9~13.5) | 6.2±0.7(−4.1~16.4) | <0.0001 |
P value (baseline vs.18 months) | 0.01 | <0.0001 | |
WMSI (17-segment model) | |||
Baseline | |||
Mean | 1.28±0.03(1.23~1.34) | 1.29±0.03(1.24~1.34) | 0.76 |
4 Months | |||
Mean | 1.16±0.02(1.11~1.21) | 1.10±0.01(1.07~1.12) | 0.02 |
Difference | −0.12±0.02(−0.16~−0.09) | −0.19±0.02(−0.23~−0.16) | 0.003 |
P value (baseline vs.6 months) | <0.0001 | <0.0001 | |
12 Months | |||
Mean | 1.15±0.02(1.11~1.20) | 1.09±0.02(1.06~1.12) | 0.02 |
Difference | −0.13±0.02( −0.17~−0.10) | −0.20±0.02(−0.23~−0.17) | 0.003 |
P value (baseline vs.12 months) | <0.0001 | <0.0001 | |
18 Months | |||
Mean | 1.16±0.9(1.02~1.40) | 1.07±0.01(1.00~1.17) | <0.0001 |
Difference | −0.13±0.02(−0.42~0.08) | −0.22±0.02(−0.57~0.04) | 0.01 |
P value (baseline vs.18 months) | <0.0001 | <0.0001 | |
End-systolic volume (ml) | |||
Baseline | |||
Mean | 66.0±3.1(59.8~72.2) | 63.1±2.8(57.5~68.7) | 0.38 |
4 Months | |||
Mean | 63.4±2.8(57.7~69.0) | 55.9±2.1(51.7~60.2) | 0.07 |
Difference | −2.6±1.8(−6.4~1.1) | −7.2±1.9(−10.9~−3.5) | 0.09 |
P value (baseline vs.6 months) | 0.16 | 0.0003 | |
12 Months | |||
Mean | 62.5±2.8(56.9~68.0) | 55.1±2.1(50.9~59.4) | 0.06 |
Difference | −3.5±1.9(−7.3~0.2) | −8.0±2.0(−12.1~−3.9) | 0.12 |
P value (baseline vs.12 months) | 0.11 | 0.0002 | |
18 Months | |||
Mean | 62.8±0.9(59.1~66.6) | 49.2±1.0(47.1~51.2) | <0.0001 |
Difference | −2. 9±2.1(−7.1~1.3) | −14.0±2.2(−18.4~−9.5) | 0.0004 |
P value (baseline vs.18 months) | 0.2 | <0.0001 | |
End-diastolic volume (ml) | |||
Baseline | |||
Mean | 132.2±3.9(124.3~140.0) | 130.3±3.8(122.7~137.9) | 0.49 |
4 Months | |||
Mean | 136.0±4.0(127.9~144.0) | 133.2±3.2(126.8~139.5) | 0.72 |
Difference | 3.8±2.3(−0.7~8.4) | 2.9±2.6(−2.3~8.0) | 0.78 |
P value (baseline vs.6 months) | 0.20 | 0.07 | |
12 Months | |||
Mean | 134.5±3.9(126.6~142.4) | 131.9±3.1(125.8~138.1) | 0.60 |
Difference | 2.4±2.5(−2.6~7.3) | 1.6±2.8(−4.0~7.2) | 0.84 |
P value (baseline vs.12 months) | 0.45 | 0.22 | |
18 Months | |||
Mean | 136.4±3.1(130.1~142.7) | 122.7±1.6 (119.5~125.8) | 0.0001 |
Difference | 4.1±2.4(−0.8~9.0) | −7.6±3.13(−13.9~−1.4) | 0.004 |
P value (baseline vs.18 months) | 0.1 | <0.0001 |