Variable | Levels simulated |
---|---|
Vaccination age for fitting databases | EPI cohort 6, 10, 14 weeks |
5-17 month cohort all children ages between 5-17 months first dose, and for third dose 8-20 months | |
Vaccination age in predictions databases | EPI schedule 6, 10, 14 weeks |
Extended routine vaccination schedule : 6, 7.5 and 9 months | |
Boosting is 18 months post third dose (EPI 21 months, extended routine 27 months) | |
Model variants [11] | 1) R0000 Base model |
2) R0068 Heterogeneity in transmission: within-host variability | |
3) R0131 Immunity decay in effective cumulative exposure | |
4) R0132 Immunity decay in immune proxies | |
5) R0133 Immunity decay in both immune proxies and effective cumulative exposure | |
6) R0670 Heterogeneity in susceptibility to co-morbidity | |
EIR | 0.1a,1,2,4,8,16,64,256 |
Access to uncomplicated case management b (%) | 0,5,40 |
Access inpatient care for severe cases c (%) | 0,100 (for fitting 0,40,80) |
Vaccination coverage d (%) | 0,100 |
Initial efficacy against infection (%) | 30,50,65,80,95 (for fitting 20,30,40,50,60,85) |
Half-life (years) | 1,2,5 |
Weibull decay shape parameter (k) | k=1 (exponential) |
k=0.5 (bi-phasic) | |
k=2 (slow decay, followed by quick decay) |