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Table 3 Diagnostic performance of absolute 3-hour change in troponin I concentration

From: Identification of acute myocardial infarction in patients with atrial fibrillation and chest pain with a contemporary sensitive troponin I assay

 

Cut-off

Sensitivity

Specificity

PPV

NPV

[ng/mL]

(95 % CI)

(95 % CI)

(95 % CI)

(95 % CI)

Absolute 3-h change in troponin I concentration

n=298, n=54 patients with MI type 1

Absolute 3-h change threshold optimized for:

Sum of sensitivity and specificity

0.011

0.83 (0.71-0.92)

0.90 (0.85-0.93)

0.64 (0.52-0.75)

0.96 (0.93-0.98)

Specificity

0.023

0.81 (0.69-0.91)

0.94 (0.91-0.97)

0.76 (0.63-0.86)

0.96 (0.92-0.98)

Absolute 3-h change in troponin I concentration and troponin I on admission above 99th percentile cut-off

n=66, n=46 patients with MI type 1

Absolute 3-h change threshold optimized for:

Sum of sensitivity and specificity

0.011

0.80 (0.66-0.91)

0.55 (0.32-0.77)

0.80 (0.66-0.91)

0.55 (0.32-0.77)

Specificity

0.023

0.80 (0.66-0.91)

0.70 (0.46-0.88)

0.86 (0.72-0.95)

0.61 (0.39-0.80)

Absolute 3-h change in troponin I concentration and troponin I on admission above unweighted optimized cut-off

n=61, n=44 patients with MI type 1

Absolute 3-h change threshold optimized for:

Sum of sensitivity and specificity

0.011

0.80 (0.65-0.90)

0.65 (0.38-0.86)

0.85 (0.71-0.94)

0.55 (0.32-0.77)

Specificity

0.023

0.80 (0.65-0.90)

0.82 (0.57-0.96)

0.92 (0.79-0.98)

0.61 (0.39-0.80)

Absolute 3-h change in troponin I concentration and troponin I on admission above specificity-optimized cut-off

n=41, n=36 patients with MI type 1

Absolute 3-h change threshold optimized for

Sum of sensitivity and specificity

0.011

0.75 (0.58-0.88)

0.80 (0.28-0.99)

0.96 (0.82-1)

0.31 (0.09-0.61)

Specificity

0.023

0.75 (0.58-0.88)

0.80 (0.28-0.99)

0.96 (0.82-1)

0.31 (0.09-0.61)