From: The variable phenotype and low-risk nature of RAS-positive thyroid nodules
Mutation | Positive predictive value (test specificity) | Tumor size (cm) | Histological subtype | Lymphovascular invasion | Extrathyroidal extension | Lymph node metastases |
---|---|---|---|---|---|---|
RAS-positive cancers (n = 8) | 47 % (97.3 %) | Range: 1.0–3.6 Median: 1.9 | 8 – follicular variant PTC | 0/8 (0 %) | 0/8 (0 %) | 0/8 (0 %) |
BRAF-positive cancers (n = 8a) | 100 % (100 %) | Range: 1.0–4.8 Median: 1.4 | 6 – classical variant PTCb 1 – tall cell variant PTC 1 – follicular variant PTC | 5/8 (62.5 %) | 1/8 (12.5 %) | 1/8 (12.5 %) |