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Table 1 Systemic adjuvant therapy options for operable breast cancer

From: Progress in adjuvant chemotherapy for breast cancer: an overview

Breast cancer subtype/classification

Adjuvant systemic therapy

Phenotypic subtype

Intrinsic subtype

Endocrine therapy

Anti-HER2 therapy

Chemotherapy

Hormone receptors

HER2 overexpression

    

+

–

Luminal A or B

Yes

No

Yes (if high risk)

+

+

Luminal B or HER2 enriched

Yes

Yes

Yes

–

–

Basal

No

No

Yes

–

+

HER2 enriched

No

Yes

Yes