a) 3.5 % discount (Base case) | |||||||
Extension to | 2–4 | 50–64 | 5–16 | 2–4 + 50–64 | 2–16 | 2–16 + 50–64 | 2–64 |
ICER | 2613 | 7350 | 1745 | 5637 | 1949 | 3073 | 5046 |
Net benefit in mil £ | 74 | 91 | 460 | 164 | 521 | 604 | 819 |
Lower | 12 | –8 | 94 | 9 | 104 | 93 | 65 |
Higher | 266 | 385 | 1577 | 614 | 1785 | 2107 | 3046 |
b) 1.5 % discount | |||||||
Extension to | 2–4 | 50–64 | 5–16 | 2–4 + 50–64 | 2–16 | 2–16 + 50–64 | 2–64 |
ICER | 2509 | 7030 | 1675 | 5398 | 1869 | 2943 | 4818 |
Net benefit | 79 | 99 | 487 | 177 | 551 | 642 | 875 |
Lower | 15 | –2 | 115 | 17 | 126 | 118 | 108 |
Higher | 272 | 394 | 1615 | 626 | 1820 | 2141 | 3090 |
c) 0 % discount | |||||||
Extension to | 2–4 | 50–64 | 5–16 | 2–4 + 50–64 | 2–16 | 2–16 + 50–64 | 2–64 |
ICER | 2406 | 6715 | 1604 | 5162 | 1788 | 2813 | 4590 |
Net benefit | 83 | 107 | 515 | 190 | 584 | 680 | 941 |
Lower | 18 | 3 | 135 | 25 | 148 | 153 | 159 |
Higher | 276 | 401 | 1643 | 639 | 1864 | 2174 | 3139 |
d) Risk groups vaccinated with a 75 % coverage | |||||||
Extension to | 2–4 | 50–64 | 5–16 | 2–4 + 50–64 | 2–16 | 2–16 + 50–64 | 2–64 |
ICER | 2748 | 8677 | 2393 | 6655 | 2618 | 3844 | 6667 |
Net benefit | 72 | 86 | 417 | 158 | 463 | 520 | 592 |
Lower | 11 | –17 | 71 | –3 | 75 | 59 | –17 |
Higher | 258 | 381 | 1438 | 600 | 1607 | 1847 | 2411 |