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Table 3 AUC, specificity, sensitivity, and accuracy of the ROC models (in %)

From: Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

 

All

Cases diagnosed <2 years

Cases diagnosed ≥2 years

 

AUC

Spe

Sen

Acc

AUC

Spe

Sen

Acc

AUC

Spe

Sen

Acc

AFPa

73

65.3

71.9

67.5

81

79

77.3

78.5

71

60.9

74

65.3

Liver function scoreb

80

84.7

70.2

79.8

79

88.4

68.2

81.5

80

83.8

70.6

79.3

O-PLS scorec

85

81.5

71.1

78.1

93

83.7

86.4

84.6

79

74.9

68.5

72.7

O-PLS CV statusd

74

68

68.4

68.1

82

100

63.6

87.7

71

68.7

67.4

68.3

O-PLS CV status + AFPe

75

80.6

75.4

78.9

82

100

63.6

87.7

73

70.9

70.6

70.8

O-PLS CV status + liver scoref

82

68

68.4

68.1

84

86

77.3

83

80

83.8

70.7

79.3

  1. AUC, Area under the curve; Spe, Specificity; Sen, Sensitivity; Acc, Accuracy of the model
  2. aModel based on the serum AFP concentration
  3. bModel based on the liver function score
  4. cModel based on the score of the O-PLS analysis
  5. dModel based on the cross-validated (CV) case/control status of the O-PLS analysis
  6. eCombination between the CV status of the O-PLS and the AFP variable
  7. fCombination between the CV status of the O-PLS and the liver function score