Circulatory disease (n = 2,404) | Cerebrovascular disease (n = 808) | Ischaemic heart disease (n = 732) | |||||
---|---|---|---|---|---|---|---|
ICD-10 codes | I00–I99 | I60–I69 | I20–I25 | ||||
Variable | Value | Cases / non-cases | HRa (95 % CI) | Cases / non-cases | HRa (95 % CI) | Cases / non-cases | HRa (95 % CI) |
Parous | Yes | 1,970 / 264,637 | 0.86 (0.76–0.96) | 655 / 265,952 | 0.93 (0.76–1.13) | 598 / 266,009 | 0.79 (0.65-0.97) |
Number of FTPsb | 1 | 374 / 47,810 | 1.00 (reference) | 114 / 48,070 | 1.00 (reference) | 117 / 48,067 | 1.00 (reference) |
2 | 799 / 126,649 | 0.92 (0.81–1.04) | 281 / 127,167 | 1.06 (0.85–1.32) | 240 / 127,208 | 0.91 (0.73-1.14) | |
3 | 431 / 58,411 | 0.88 (0.76–1.02) | 135 / 58,707 | 0.90 (0.70–1.17) | 139 / 58,703 | 0.93 (0.73-1.20) | |
4 | 198 / 17,124 | 0.95 (0.79–1.13) | 66 / 17,256 | 1.03 (0.75–1.41) | 48 / 17,274 | 0.74 (0.52-1.05) | |
5 | 63 / 4,735 | 0.85 (0.65–1.12) | 21 / 4,777 | 0.92 (0.57–1.48) | 18 / 4,780 | 0.78 (0.47-1.29) | |
≥6 | 62 / 2,464 | 1.13 (0.85–1.50) | 23 / 2,503 | 1.49 (0.93–2.39) | 19 / 2,507 | 1.12 (0.67-1.88) | |
P for trendc | 0.85 | 0.42 | 0.29 | ||||
Age at first FTP, yearsd | ≤20 | 304 / 38,897 | 1.15 (0.99–1.34) | 97 / 39,104 | 1.14 (0.86–1.50) | 105 / 39,096 | 1.14 (0.86-1.51) |
21–23 | 497 / 70,825 | 1.11 (0.98–1.26) | 150 / 71,172 | 0.96 (0.76–1.23) | 140 / 71,182 | 0.96 (0.74-1.24) | |
24–25 | 359 / 51,697 | 1.05 (0.92–1.20) | 122 / 51,934 | 1.00 (reference) | 106 / 51,950 | 1.00 (reference) | |
26–30 | 557 / 75,370 | 1.00 (reference) | 199 / 75,728 | 0.97 (0.78–1.23) | 166 / 75,761 | 0.99 (0.77-1.26) | |
≥31 | 237 / 26,790 | 1.06 (0.90–1.23) | 79 / 26,948 | 0.90 (0.67–1.21) | 74 / 26,953 | 1.10 (0.81-1.49) | |
Breastfeedingd | Ever | 1,534 / 210,507 | 0.80 (0.70–0.91) | 526 / 211,515 | 0.94 (0.74–1.21) | 445 / 211,596 | 0.69 (0.54-0.87) |
Breastfeeding, monthse | ≤1 | 135 / 20,835 | 1.00 (reference) | 38 / 20,932 | 1.00 (reference) | 41 / 20,929 | 1.00 (reference) |
>1 to ≤3 | 282 / 41,403 | 1.16 (0.94–1.43) | 101 / 41,584 | 1.47 (1.00–2.14) | 86 / 41,599 | 1.22 (0.83-1.79) | |
>3 to ≤6 | 276 / 43,251 | 1.05 (0.85–1.30) | 93 / 43,434 | 1.20 (0.82–1.77) | 91 / 43,436 | 1.22 (0.83-1.79) | |
>6 to ≤12 | 359 / 49,662 | 1.02 (0.83–1.26) | 115 / 49,906 | 1.10 (0.75–1.60) | 102 / 49,919 | 0.99 (0.68-1.45) | |
>12 to ≤18 | 184 / 24,118 | 0.98 (0.78–1.23) | 69 / 24,233 | 1.18 (0.78–1.77) | 51 / 24,251 | 0.94 (0.61-1.44) | |
>18 | 287 / 28,936 | 1.04 (0.83–1.31) | 110 / 29,113 | 1.28 (0.85–1.90) | 71 / 29,152 | 0.92 (0.60-1.40) | |
P for trendc | 0.48 | 0.076 | 0.153 | ||||
OC use in never or former | Never | 1,274 / 105,390 | 1.00 (reference) | 467 / 106,197 | 1.00 (reference) | 352 / 106,312 | 1.00 (reference) |
smokers at baselinef | Ever | 427 / 143,935 | 0.85 (0.75–0.97) | 144 / 144,218 | 0.80 (0.64–1.01) | 102 / 144,260 | 0.87 (0.67-1.12) |
Formerg | 397 / 125,478 | 0.84 (0.74–0.96) | 129 / 125,746 | 0.78 (0.62–0.98) | 100 / 125,775 | 0.87 (0.67-1.13) | |
Currentg,h | 22 / 13,075 | 1.48 (0.90–2.43) | 13 / 13,084 | 2.62 (1.30–5.26) | 2 / 13,095 | - | |
Duration of OC use, yearsf,i | ≤1 | 72 / 26,096 | 1.00 (reference) | 23 / 26,145 | 1.00 (reference) | 21 / 26,147 | 1.00 (reference) |
>1 to <5 | 72 / 31,247 | 0.95 (0.68–1.33) | 23 / 31,296 | 0.95 (0.52–1.73) | 21 / 31,298 | 0.97 (0.52-1.83) | |
5 to <10 | 80 / 31,480 | 0.98 (0.70–1.36) | 34 / 31,526 | 1.40 (0.80–2.44) | 14 / 31,546 | 0.58 (0.29-1.16) | |
10 to <15 | 84 / 21,797 | 1.22 (0.88–1.70) | 22 / 21,859 | 1.08 (0.59–2.00) | 22 / 21,859 | 1.09 (0.58-2.05) | |
≥15 | 70 / 19,032 | 1.14 (0.80–1.62) | 30 / 19,072 | 1.63 (0.91–2.94) | 15 / 19,087 | 0.96 (0.48-1.94) | |
P for trendc | 0.38 | 0.177 | 0.91 | ||||
Age at menarche, years | <12 | 325 / 47,412 | 1.00 (reference) | 105 / 47,632 | 1.00 (reference) | 107 / 47,630 | 1.00 (reference) |
12 | 411 / 67,956 | 0.84 (0.73–0.98) | 132 / 68,235 | 0.80 (0.62–1.04) | 123 / 68,244 | 0.80 (0.62-1.04) | |
13 | 555 / 82,511 | 0.89 (0.77–1.02) | 186 / 82,880 | 0.86 (0.67–1.09) | 165 / 82,901 | 0.81 (0.63-1.03) | |
14 | 559 / 68,815 | 0.91 (0.79–1.05) | 189 / 69,185 | 0.88 (0.69–1.12) | 164 / 69,210 | 0.80 (0.62-1.02) | |
≥15 | 494 / 50,019 | 0.83 (0.72–0.96) | 165 / 50,348 | 0.79 (0.61–1.02) | 160 / 50,353 | 0.80 (0.62-1.03) | |
P for trendc | 0.47 | 0.51 | 0.30 | ||||
Age at natural menopause, yearsj | ≤45 | 251 / 13,225 | 1.07 (0.91–1.25) | 78 / 13,398 | 1.00 (0.75–1.32) | 85 / 13,391 | 1.14 (0.86-1.50) |
46–50 | 499 / 34,410 | 1.00 (reference) | 163 / 34,746 | 1.00 (reference) | 157 / 34,752 | 1.00 (reference) | |
51–52 | 189 / 15,410 | 0.79 (0.67–0.94) | 68 / 15,531 | 0.83 (0.62–1.12) | 43 / 15,556 | 0.58 (0.41-0.82) | |
53–55 | 166 / 13,589 | 0.75 (0.63–0.90) | 54 / 13,701 | 0.71 (0.52–0.97) | 45 / 13,710 | 0.67 (0.48-0.94) | |
>55 | 64 / 3,560 | 0.85 (0.65–1.11) | 22 / 3,602 | 0.81 (0.51–1.28) | 17 / 3,607 | 0.71 (0.42-1.18) | |
P for trendc | <0.001 | 0.088 | <0.001 |