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Table 1 Clinical and biological characteristics of the study population

From: RNY-derived small RNAs as a signature of coronary artery disease

 

Cases (n = 263)

Controls (n = 514)

P value

Age (years)

60.3 (8.0)

59.0 (8.3)

0.04

Education (years of schooling)

9.6 (3.0)

13.1 (4.3)

0.001 a

Alcohol (g/day)

28.8 (28.5)

23.8 (24.1)

0.09 a

Tobacco consumption number (pack/year)

41.5 (37.9)

17.2 (21.3)

0.001 a

Physical activity (%)

  

0.001

 No

27.4

18.5

 

 Medium

61.6

45.9

 

 High

11.0

35.6

 

Waist (cm)

99.3 (10.7)

95.3 (9.9)

0.001

Body mass index (kg/m2)

27.5 (4.0)

26.9 (3.6)

0.04

Total cholesterol (g/L)

2.02 (0.38)

2.24 (0.38)

0.001

HDL-cholesterol (g/L)

0.43 (0.12)

0.55 (0.13)

0.001

LDL-cholesterol (g/L)

1.25 (0.34)

1.45 (0.32)

0.001

Triglyceride (g/L)

1.68 (0.89)

1.21 (0.77)

0.001 b

ApoA-I (g/L)

1.23 (0.22)

1.50 (0.24)

0.001

ApoB (g/L)

1.04 (0.22)

1.08 (0.22)

0.03

Lipoprotein (a) (g/L)

0.47 (0.44)

0.30 (0.37)

0.001 b

hs-CRP (mg/L)

17.2 (29.7)

3.1 (5.1)

0.001 a

Gamma glutamyl transferase (IU/L)

62.8 (68.6)

45.2 (56.8)

0.001 a

Fasting glucose (mmol/L)

5.93 (2.01)

5.43 (1.06)

0.19 a

Serum insulin (UI/L)

15.9 (19.5)

10.0 (8.1)

0.001 a

HOMA-IR

4.2 (4.8)

2.6 (2.8)

0.001 a

Metabolic syndrome (NCEP ATP-III %)

48.5

17.7

0.001

Systolic blood pressure (mmHg)

137.0 (20.2)

137.4 (16.5)

0.82 a

Resting heart rate (beat/mn)

63.7 (11.5)

62.8 (9.2)

0.79 a

Ankle-arm index ≤0.9 (%)

33.6

1.6

0.001

Treatment for hypertension (%)

44.1

19.6

0.001

Treatment for diabetes (%)

23.2

5.2

0.001

Treatment for dyslipidemia (%)

63.5

23.3

0.001

s-RNY1-5p

10.42 (12.33)

1.32 (1.67)

0.001 a

(RNY1-5p)1/7

1.33 (0.18)

0.95 (0.19)

0.001

Quartiles RNY1-5p (%)

  

0.001

 Q1 : <0.47

0.4

37.9

 

 Q2 : 0.47–1.62

5.3

34.6

 

 Q3 : 1.61–4.70

28.5

23.4

 

 Q4 : >4.70

65.8

4.1

 
  1. Data are expressed as mean (±SD) or percentage (%)
  2. a Wilcoxon–Mann–Whitney test
  3. b Analyses performed on log transformed data
  4. ApoA-I, Apolipoprotein A-I; ApoB, Apolipoprotein B; hs-CRP, High sensitive C-reactive protein; HOMA-IR, Homeostatic model assessment-insulin resistance; NCEP ATP-III, National Cholesterol Education Program’s Adult Treatment Panel III report