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Table 2 Univariate and multivariate analysis of survival for ER and PgR subgroups

From: Molecular essence and endocrine responsiveness of estrogen receptor-negative, progesterone receptor-positive, and HER2-negative breast cancer

Subgroups

Cohort 1: BCSS

Cohort 2: RFS

Cohort 3: RFS

Cohort 4: DRFS

 

HR (95 % CI)

P1

P2

HR (95 % CI)

P1

P2

HR (95 % CI)

P1

P2

HR (95 % CI)

P1

P2

 

Univariate

Adjusteda

  

Univariate

Adjusteda

  

Univariate

Adjustedb

  

Univariate

Adjustedc

  

ER+/PgR+

1 (ref.)

1 (ref.)

<0.001d

 

1 (ref.)

1 (ref.)

<0.001d

 

1 (ref.)

1 (ref.)

0.006d

 

1 (ref.)

1 (ref.)

<0.001d

 

ER−/PgR+

4.67 (2.55–8.57)

3.26 (1.71–6.22)

<0.001

<0.001

2.76 (1.27–5.99)

2.61 (1.20–5.67)

0.017

0.016

2.51 (1.11–5.68)

2.68 (1.10–6.55)

0.028

0.030

0.78 (0.19–3.27)

1.09 (0.26–4.64)

0.79

0.90

ER−/PgR−

7.26 (6.10–8.64)

4.12 (3.33–5.09)

<0.001

<0.001

3.65 (2.71–4.92)

4.10 (3.03–5.54)

<0.001

<0.001

2.59 (1.36–4.93)

2.51 (1.21–5.20)

0.003

0.013

3.33 (2.16–5.15)

3.66 (2.15–6.23)

<0.001

<0.001

  1. Here we provided both unadjusted and adjusted values of HR of BCSS/RFS/DRFS to show the survival effect of ER/PgR status
  2. P1: Pairwise P value for univariate analysis (by log-rank test). ER+/PgR+ group as reference
  3. P2: Pairwise P value for multivariate analysis (by Cox regression). ER+/PgR+ group as reference
  4. BCSS Breast cancer-specific survival, CI Confidence interval, DRFS Distant relapse-free survival, HR Hazard ratio, ref Reference, RFS Relapse-free survival
  5. aAdjusted for age, tumor size, lymph nodes status, and grade
  6. bAdjusted for age, lymph nodes status, and grade. Tumor size is not adjusted because only half of cases have available information on it
  7. cAdjusted for age, tumor size, lymph nodes status, grade, and pathological complete response
  8. dOverall P value for univariate analysis (by log-rank test)