Table 3 Relationship between immunohistochemistry-based subgroups and PAM50-based intrinsic subtypes
| Â | Â | Gene-expression based subtype (by PAM50 classifier) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
IHC-based subgroup (HER2–) | Total (n) | Luminal-A (n) | % | Luminal-B (n) | % | Basal (n) | % | HER2+ (n) | % | Normal-like (n) | % | P |
Cohort 3 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | <0.001 |
 ER+/PgR+ | 391 | 179 | 45.8 | 168 | 43.0 | 20 | 5.1 | 7 | 1.8 | 17 | 4.3 |  |
 ER−/PgR+ | 36 | 6 | 16.7 | 6 | 16.7 | 20 | 55.6 | 3 | 8.3 | 1 | 2.8 |  |
 ER−/PgR− | 280 | 9 | 3.2 | 27 | 9.6 | 207 | 73.9 | 25 | 8.9 | 12 | 4.3 |  |
Cohort 4 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | <0.001 |
 ER+/PgR+ | 216 | 126 | 58.3 | 50 | 23.1 | 13 | 6.0 | 12 | 5.6 | 15 | 6.9 |  |
 ER−/PgR+ | 17 | 3 | 17.6 | 1 | 5.9 | 11 | 64.7 | 1 | 5.9 | 1 | 5.9 |  |
 ER−/PgR− | 178 | 2 | 1.1 | 3 | 1.7 | 142 | 79.8 | 14 | 7.9 | 17 | 9.6 |  |