Table 2 The independent association between age at diagnosis and somatic mutations
From: Genomic aberrations in young and elderly breast cancer patients
Young age | Intermediate age | Older age | Logistic model | FDR | |
|---|---|---|---|---|---|
(≤45 years, n = 118) | (46–69 years, n = 449) | (≥70 years, n = 155) | (P value)a | ||
Mutations independently associated with young age at diagnosis | |||||
GATA3 | 18 (15.2 %) | 37 (8.2 %) | 14 (9 %) | 0.003 | 0.033 |
Mutations independently associated with older age at diagnosis | |||||
TTN | 16 (13.5 %) | 68 (15.1 %) | 45 (29 %) | 0.0003 | 0.01 |
KMT2D | 1 (0.8 %) | 9 (2 %) | 9 (5.8 %) | 0.0003 | 0.01 |
CSPP1 | 0 | 3 (0.6 %) | 8 (5.1 %) | 0.0002 | 0.01 |
FOXA1 | 1 (0.8 %) | 6 (1.3 %) | 9 (5.8 %) | 0.0009 | 0.013 |
XIST | 0 | 6 (1.3 %) | 9 (5.8 %) | 0.0008 | 0.013 |
KMT2C | 4 (3.3 %) | 26 (5.7 %) | 18 (11.6 %) | 0.002 | 0.027 |
SYNE2 | 3 (2.5 %) | 16 (3.5 %) | 13 (8.3 %) | 0.005 | 0.033 |
SPEN | 2 (1.6 %) | 13 (2.8 %) | 12 (7.7 %) | 0.005 | 0.033 |
USP34 | 1 (0.8 %) | 12 (2.6 %) | 9 (5.8 %) | 0.004 | 0.033 |
ANK2 | 0 | 11 (2.4 %) | 9 (5.8 %) | 0.007 | 0.043 |