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Fig. 1 | BMC Medicine

Fig. 1

From: Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin–angiotensin system

Fig. 1

Effect of intramedullary (pro)renin receptor (PRR) inhibition on angiotensin II (AngII)-induced hypertension in rats. Uninephrectomized male Sprague-Dawley rats were divided into the following three groups: (1) AngII, (2) AngII + intramedullary PRO20 infusion (IM PRO20), and (3) AngII + intravenous PRO20 infusion (IV PRO20). AngII was subcutaneously infused at 100 ng/kg/min via an osmotic mini-pump. IM PRO20 (PRO20 at 120 μg/kg/d) was performed via a catheter chronically implanted in the renal medulla. To control the spillover, IV PRO (PRO20 at 120 μg/kg/d) was performed via catheterization of the jugular vein. Telemetry was performed to monitor mean arterial pressure (MAP) and it was turned on 4 h per day from 5:00 p.m. to 9:00 p.m. for 7 days. a Radiotelemetry monitoring of MAP. # P < 0.01 versus intravenous PRO20; *P < 0.05 versus AngII alone. b Cardiac hypertrophy. Heart weight is expressed as percentage of body weight. Control (CTR), N = 6; AngII + Vehicle, N = 9; AngII + IM PRO20, N = 8; AngII + IV PRO20, N = 6. Data are mean ± standard error

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