Table 5 Association of derivatives of reactive oxygen metabolites (d-ROMs) levels and total thiol levels (TTL) with all-cause and disease specific mortality stratified by cohort/country, sex, age, history of myocardial infarction, history of cancer, inflammatory status and time-point of event during follow-up

All-cause mortality

HAPIEE Poland

525

1.29 (1.14–1.46)*

1.14 (1.01–1.28)*

HAPIEE Czech Republic

518

1.33 (1.17–1.51)*

1.05 (0.93–1.19)

HAPIEE Lithuania

390

1.47 (1.25–1.71)*

1.31 (1.10–1.57)*

ESTHER (Germany)

269

1.33 (1.18–1.49)*

1.31 (1.15–1.48)*

CVD mortality

HAPIEE Poland

165

1.54 (1.21–1.95)*

1.22 (0.98–1.53)

HAPIEE Czech Republic

189

1.56 (1.22–2.00)*

1.25 (0.99–1.56)

HAPIEE Lithuania

155

1.40 (1.06–1.85)*

1.48 (1.06–2.06)*

ESTHER (Germany)

51

1.24 (0.94–1.63)

1.39 (1.06–1.84)*

Cancer mortality

HAPIEE Poland

235

1.17 (0.98–1.41)

1.06 (0.89–1.26)

HAPIEE Czech Republic

235

1.36 (1.13–1.63)*

0.95 (0.79–1.14)

HAPIEE Lithuania

158

1.60 (1.25–2.04)*

1.18 (0.89–1.55)

ESTHER (Germany)

74

1.40 (1.13–1.74)*

1.21 (0.96–1.53)

All-cause mortality

45 to <60 years^d

423

1.23 (1.04–1.45)*

1.16 (1.01–1.34)*

60 to <70 years

933

1.39 (1.27–1.53)*

1.16 (1.05–1.29)*

70 to <85 years^{e, f}

303

1.33 (1.17–1.52)*

1.35 (1.18–1.55)*

CVD mortality

45 to <60 years^d

126

1.42 (1.01–2.00)*

1.24 (0.91–1.69)

60 to <70 years^d

322

1.64 (1.35–2.00)*

1.31 (1.09–1.56)*

70 to <85 years^{e, f}

90

1.28 (0.97–1.69)

1.65 (1.22–2.24)*

Cancer mortality

45 to <60 years^d

177

1.21 (0.81–1.81)

1.20 (0.96–1.50)

60 to <70 years^d

392

1.41 (1.21–1.64)*

1.02 (0.86–1.21)

70 to <85 years^{e, f}

94

1.46 (1.13–1.87)*

1.17 (0.89–1.52)

All-cause mortality

Women

587

1.28 (1.13–1.44)*

1.25 (1.05–1.50)*

Men

1115

1.40 (1.29–1.53)*

1.18 (1.08–1.28)*

CVD mortality

Women^d

157

1.42 (1.08–1.87)*

1.28 (0.98–1.69)

Men

385

1.50 (1.27–1.76)*

1.33 (1.13–1.56)*

Cancer mortality

Women

257

1.31 (1.05–1.65)*

1.16 (0.96–1.40)

Men

445

1.39 (1.21–1.59)*

1.06 (0.93–1.21)

All-cause mortality

No history of MI

1286

1.33 (1.22–1.41)*

1.17 (1.04–2.61)*

History of MI^g

375

1.39 (1.17;1.65 )*

1.19 (0.97–1.63)

CVD mortality

No history of MI

379

1.35 (1.14–1.57)*

1.22 (1.04–1.43)*

History of MI^{d, g}

165

1.45 (1.04–2.02)*

1.19 (0.88–1.61)

All-cause mortality

No history of cancer

1382

1.32 (1.23–1.42)*

1.16 (1.05–1.29)*

History of cancer^g

257

1.49 (1.24–1.77)*

1.24 (1.00–1.54)*

Cancer mortality

No history of cancer

533

1.29 (1.15–1.45)*

1.01 (0.89–1.14)

History of cancer^g

169

1.53 (1.19–1.97)*

1.16 (0.91–1.47)

All-cause mortality

CRP ≤3 mg/L

933

1.19 (1.08–1.31)*

1.12 (0.97–1.30)

CRP >3 mg/L

769

1.26 (1.15–1.38)*

1.16 (1.05–1.28)*

CVD mortality

CRP ≤3 mg/L^d

265

1.26 (1.00–1.58)*

1.10 (0.90–1.35)

CRP >3 mg/L

275

1.28 (1.07–1.54)*

1.22 (1.01–1.48)*

Cancer mortality

CRP ≤3 mg/L

394

1.22 (1.04–1.43)*

1.06 (0.90–1.26)

CRP >3 mg/L

308

1.27 (1.10–1.46)*

1.07 (0.91–1.26)

Stratified by time-point of event during follow-up

All-cause mortality

≤ year 2

419

1.46 (1.29–1.66)*

1.29 (1.11–1.50)*

> year 2 to ≤ year 4

597

1.31 (1.17–1.46)*

1.18 (1.06–1.33)*

> year 4 to ≤ year 6

433

1.25 (1.09–1.43)*

1.17 (1.02–1.33)*