Univariate analysis | Multivariable analysis | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Variables | n | % | 5-yr DRFS | HR | Lower 95 % | Upper 95 % | P value | HR | Lower 95 % | Upper 95 % | P value |
Age, years (cont. variable) | – | – | – | 1.0 | 0.98 | 1.01 | 0.590 | 0.98 | 0.97 | 1.01 | 0.129 |
Tumor size | |||||||||||
T0-T2 | 216 | 56 % | 74 % | 1.0 | – | – | – | 1.0 | – | – | – |
T3-T4 | 173 | 44 % | 61 % | 2.1 | 1.38 | 3.07 | <0.001 | 1.5 | 1.16 | 1.92 | 0.002 |
Node status | |||||||||||
N0 | 126 | 32 % | 85 % | 1.0 | – | – | – | 1.0 | – | – | – |
N1-3 | 263 | 68 % | 66 % | 3.3 | 1.90 | 5.71 | <0.001 | 2.9 | 1.62 | 5.37 | <0.001 |
ER IHC | |||||||||||
Positive | 129 | 34 % | 78 % | 1.0 | – | – | – | 1.0 | – | – | – |
Negative | 255 | 66 % | 47 % | 4.0 | 2.69 | 6.02 | <0.001 | 1.8 | 0.87 | 3.56 | 0.114 |
PR IHC | |||||||||||
Positive | 175 | 46 % | 79 % | 1.0 | – | – | – | 1.0 | – | – | – |
Negative | 208 | 54 % | 54 % | 3.3 | 2.15 | 5.05 | <0.001 | 1.2 | 0.62 | 2.13 | 0.654 |
HER2 STATUS | |||||||||||
Negative | 373 | 99 % | 68 % | 1.0 | – | – | – | 1.0 | – | – | – |
Positive | 3 | 1 % | NA | 1.1 | 0.16 | 8.16 | 0.900 | 0.5 | 0.07 | 3.65 | 0.485 |
Histological grade | |||||||||||
1 | 28 | 8 % | 96 % | 1.0 | – | – | – | 1.0 | – | – | – |
2 | 160 | 44 % | 73 % | 6.1 | 0.83 | 44.43 | 0.076 | 2.75 | 0.36 | 20.94 | 0.33 |
3 | 175 | 48 % | 60 % | 10.9 | 1.51 | 78.73 | 0.018 | 2.54 | 0.33 | 19.66 | 0.37 |
PAM50 | |||||||||||
Luminal A | 144 | 37 % | 83 % | 1.0 | – | – | – | 1.0 | – | – | – |
Luminal B | 90 | 23 % | 74 % | 1.8 | 0.90 | 3.46 | 0.097 | 1.4 | 0.69 | 2.82 | 0.360 |
HER2-E | 30 | 8 % | 41 % | 5.9 | 3.38 | 10.30 | <0.001 | 2.7 | 1.15 | 6.41 | 0.023 |
Basal-like | 102 | 26 % | 48 % | 5.3 | 2.63 | 10.84 | <0.001 | 2.8 | 1.19 | 6.42 | 0.018 |
Normal-like | 23 | 6 % | 82 % | 1.6 | 0.55 | 4.85 | 0.380 | – | – | – | – |