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Table 3 Analysis of neutropenia across all treatments (classification National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) grade ≥1 vs. grade 0)

From: A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities

Toxicity

n (univariable analysis)

n (multivariable analysis)

BCSS

RFS

Unadjusted

Adjusted

Unadjusted

Adjusted

HR (95 % CI)

P value

HR (95 % CI)

P value

HR (95 % CI)

P value

HR (95 % CI)

P value

Neutropenia

5,886

5,211

0.86 (0.77–0.96)

0.009

0.87 (0.77–0.99)

0.03

0.91 (0.83–0.99)

0.04

0.91 (0.82–1.01)

0.07

  1. BCSS Breast cancer-specific survival; RFS Relapse-free survival; HR Hazard ratio; CI, Confidence interval