Table 1 Characteristics of 29 selected systematic reviews
Systematic review | Last search | Publication date | Number of trials | Funding source | Intervention | Comparator | Specific treatment | Different treatments lumped together | Different types of treatments lumped together |
|---|---|---|---|---|---|---|---|---|---|
Bonfill 2002 | Jul 2001 | Apr 2001 | 1 | Non-industry | CTx | PBO or BSC | No | Yes | No |
Tassinari 2009 | Jul 2008 | Feb 2009 | 3 | NR | CTx or EGFRTKI | BSC | No | Yes | Yes |
Yang 2014 | Dec 2013 | May 2014 | 2 | NR | EGFRTKI | PBO | No | Yes | No |
Wong 2013‡ | SMay 2012 | Oct 2013 | 4 | NR | EGFRTKI | CTx or PBO | No | Yes | Yes |
Barlesi 2006 | Feb 2005 | Dec 2005 | 4 | NR | DOC | CTx or BSC | No | Yes | Yes |
Al-Saleh 2012 | Jan 2010 | Feb 2012 | 1 | Industry | PEM | CTx | Yes | Yes | No |
Perez-Moreno 2014 | Apr 2012 | Mar 2014 | 1 | Non-industry | PEM | CTx | Yes | Yes | No |
Jiang 2011 | Feb 2010 | Dec 2010 | 4 | Non-industry | GEF | DOC | Yes | No | No |
Qi 2012c | Mar 2012 | Oct 2012 | 8 | Non-industry | EGFRTKI | CTx | No | Yes | No |
Gao 2013‡ | NR | Jun 2013 | 3 | NR | EGFRTKI | CTx | No | Yes | No |
Lee 2014 | Dec 2013 | Apr 2014 | 7 | Non-industry | EGFRTKI | CTx | No | Yes | No |
Zhao 2014 | Jul 2013 | Apr 2014 | 6 | Non-industry | EGFRTKI | CTx | No | Yes | No |
Li 2014b | Jul 2013 | Jul 2014 | 10 | None | EGFRTKI | CTx | No | Yes | No |
Vale 2014 | Jan 2014 | Nov 2014 | 14 | Non-industry | EGFRTKI | CTx | No | Yes | No |
Qi 2012a | Mar 2011 | May 2011 | 8 | NR | DOC + (CTx or TT) | DOC | No | Yes | Yes |
Jin 2014* | Dec 2013 | Sep 2014 | 12 | Non-industry | DOC + (CTx or TT) | DOC | No | Yes | Yes |
Qi 2012b | May 2011 | Jan 2012 | 5 | NR | PEM + (CTx or TT) | PEM | No | Yes | Yes |
Sun 2014 | Feb 2012 | Apr 2014 | 4 | NR | PEM + (CTx or TT) | PEM | No | Yes | Yes |
Qi 2011 | Jul 2011 | Oct 2011 | 4 | NR | CTx + VAN or VAN | CTx or EGFRTKI | Yes | Yes | Yes |
Tao 2012 | Sep 2011 | Mar 2012 | 5 | NR | CTx + VAN or VAN | CTx or EGFRTKI | Yes | Yes | Yes |
Tassinari 2012 | Jun 2010 | Dec 2012 | 4 | NR | DOC | CTx or EGFRTKI | No | Yes | Yes |
Qi 2013 | May 2012 | Feb 2013 | 8 | Non-industry | ERL + TT | ERL | No | Yes | No |
Cui 2013 | Dec 2011 | Apr 2013 | 8 | Non-industry | BEV + (CTx or EGFRTKI) | CTx or EGFRTKI | Yes | Yes | Yes |
| Â | Â | Â | Â | Â | EGFRTKI | CTx or PBO | No | Yes | Yes |
Li 2014a | Dec 2013 | Apr 2014 | 14 | None | CTx + TT | CTx | No | Yes | No |
Liang 2014 | Jan 2014 | Oct 2014 | 10 | Non-industry | MATKI + (CTx or EGFRTKI) or MATKI | CTx or EGFRTKI or PBO | No | Yes | Yes |
Sun 2015 | Oct 2014 | Jan 2015 | 2 | NR | BEV + EGFRTKI | EGFRTKI | No | Yes | No |
Xiao 2015 | Sep 2014 | Feb 2015 | 5 | Non-industry | CTx + EGFRTKI | CTx or EGFRTKI | No | Yes | Yes |
Hawkins 2009†| Oct 2007 | Apr 2009 | 6 | Industry | DOC vs PEM vs ERL vs GEF | No | No | No | |
Popat 2015†| Mar 2014 | Dec 2014 | 9 | Industry | CTx vs TT vs CTx + TT vs (PBO or BSC) | No | No | No | |