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Table 1 Demographic and cardiovascular risk characteristics of the D:A:D cohort over time. The information shown in the table describes the current status of each individual under follow-up on 1 January each year (based on the last available measurement for that individual prior to the start of the year)

From: Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration

  

Individuals under follow-up on 1 January of year:

  

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012

N

 

3,508

20,868

22,816

25,694

27,148

28,526

29,570

30,549

31,832

35,146

34,438

32,662

31,112

Male (%)

 

79.8

75.2

75.5

74.7

74.1

73.3

73.0

72.8

73.1

73.2

73.5

73.5

73.6

Age (years)

Median

39

39

40

41

42

43

44

45

46

47

48

49

50

Previous AIDS (%)

 

25.9

25.8

26.3

26.3

26.6

26.7

26.8

27.1

26.9

26.5

26.9

27.5

27.8

10-year CVD risk (%)

Low

5.1

35.7

42.3

45.4

49.5

52.8

57.0

61.9

64.2

63.9

66.8

69.8

71.7

 

Moderate

1.7

7.8

9.1

8.8

9.1

9.3

9.1

9.2

9.9

10.5

10.7

11.0

11.3

 

High

2.8

4.6

5.3

5.1

5.2

5.1

4.8

4.9

5.3

5.4

5.6

5.8

6.0

 

Unknown

90.7

51.9

43.4

40.7

36.2

32.8

29.2

24.0

20.7

20.2

16.9

13.4

11.1

Smoking statusa

Current smoker

27.2

49.2

49.6

49.0

47.2

47.5

45.5

45.0

44.1

43.8

42.7

41.0

39.8

Ex-smoker

50.6

21.4

21.8

20.8

22.2

22.4

24.7

25.3

26.1

26.1

27.5

29.3

30.6

 

Never smoked

22.3

29.4

28.6

30.2

30.6

30.0

29.8

29.7

29.8

30.1

29.9

29.7

29.6

Family history of CVD (%)

5.1

8.7

8.7

8.3

8.2

8.1

8.0

8.0

7.7

7.3

7.5

7.7

7.8

Diabetes (%)

 

3.6

3.9

4.5

4.7

5.1

5.0

5.0

5.0

5.1

5.2

5.6

5.9

6.3

TC (mmol/L)

Median

5.1

5.1

5.1

5.0

5.0

4.9

4.9

4.8

4.8

4.9

4.9

4.9

5.0

HDL-C (mmol/L)

Median

1.1

1.1

1.1

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

TG (mmol/L)

Median

1.9

1.7

1.7

1.7

1.7

1.6

1.6

1.5

1.5

1.5

1.5

1.5

1.5

CD4 (cells/mm3)

Median

380

448

461

465

460

460

468

480

494

503

527

548

566

Viral load (log10 copies/ml)

Median

2.4

2.1

1.9

1.8

1.7

1.7

1.7

1.7

1.7

1.7

1.7

1.7

1.7

  1. aExpressed as a proportion of those with known smoking status, which has increased from 71.9 % of the cohort in 2000 to 89.5 % in 2012. CVD cardiovascular disease, HDL-C high-density lipoprotein cholesterol, TC total cholesterol, TG triglycerides