Main exposure/potential confounders/a priori confounders | Univariate regressiona | Multivariable regressiona | |
---|---|---|---|
OR (95 % CI) | OR (95 % CI) | ||
Hospital caseloadb | |||
114+ | P <0.001 | e | |
73–113 | 1.13 (1.00–1.29) | ||
27–72 | 1.06 (0.91–1.24) | ||
<27 | 1.32 (1.13–1.55) | ||
Notification date | |||
Post-toolkit | P <0.001 | P <0.001 | |
Pre-toolkit | 1.25 (1.17–1.33) | 1.30 (1.21–1.40) | |
Location | |||
Outside London | P <0.001 | P = 0.16 | |
Inside London | 0.81 (0.71–0.93) | 0.90 (0.77–1.04) | |
Sex | |||
Male | P <0.001 | P <0.001 | |
Female | 0.79 (0.75–0.84) | 0.85 (0.80–0.90) | |
Age, years | |||
<20 | 0.67 (0.60–0.75) | 0.70 (0.63–0.79) | |
20–39 | P <0.001 | P <0.001 | |
40–64 | 0.93 (0.87–0.99) | 0.92 (0.85–0.98) | |
65+ | 1.48 (1.37–1.59) | 1.44 (1.32–1.57) | |
Ethnic group | |||
White | P <0.001 | e | |
Black African | 0.68 (0.63–0.75) | ||
Black other | 0.88 (0.75–1.03) | ||
Indian subcontinent | 0.76 (0.71–0.82) | ||
Other | 0.74 (0.67–0.82) | ||
UK born | |||
No | P <0.001 | e | |
Yes | 1.10 (1.03–1.17) | ||
Site of diseasec | |||
Extrapulmonary only | P <0.001 | – | |
Pulmonary smear negative/unknown | 1.16 (1.09–1.23) | ||
Pulmonary smear positive | 1.52 (1.42–1.63) | ||
Drug sensitivity | |||
Sensitive | P <0.001 | – | |
Resistant to INH, EMB, or PZA | 5.40 (4.86–6.00) | ||
Not linked to a culture | 0.87 (0.82–0.92) | ||
Previous diagnosis | |||
No | P <0.001 | – | |
Yes | 1.32 (1.19–1.46) | ||
Social risk factorsd | |||
No or unknown | P <0.001 | P <0.001 | |
One or more previous | 1.33 (1.11–1.60) | 1.36 (1.12–1.66) | |
One or more current | 2.83 (2.44–3.28) | 2.67 (2.28–3.13) |