Fig. 4

The associations between patient clinical and microbiological parameters and M.tb sputa transcriptional signatures. a M.tb responses to drug therapy result in contrasting patient trajectories as defined by principle component analysis (PCA). The first (PC1) and second (PC2) principle components of the M.tb transcriptional signatures from each patient at day 0, 3, 7 and 14 are plotted. Each point represents an M.tb mRNA profile derived from a patient (coloured individually), arrows and dashed lines mark the direction and distance of movement of each patient from day 0 to day 14. Patient study identifiers are plotted at day 0. b/c Fitted (x-axis) against true (y-axis) time-to-positivity (TTP) values of test samples modelled using the displayed set of 20 genes. y=x red line indicates ideal performance of the model; RMSE 3.6 hours, Pearson correlation coefficient 0.59, p-value of 4.4×10^-5. d/e Fitted (x-axis) against true (y-axis) chest x-ray scores of test samples modelled using the displayed set of 23 genes. y=x red line indicates ideal performance of the model; RMSE 13.9 CXR score, Pearson correlation coefficient 0.73, p-value 3.7×10^-7. RMSE root mean squared error, CXR chest radiograph