From: Incorporation of tissue-based genomic biomarkers into localized prostate cancer clinics
First author and year | Number of cases | Study population | End point | Main results |
---|---|---|---|---|
Erho et al. [19] 2013 | 545 patients | Radical Prostatectomy | Metastases | Area Under Curve of 75Â % in prediction of metastases |
Karnes et al. [22] 2013 | 219 patients | Radical Prostatectomy | Metastases | Area Under Curve of 79Â % in prediction of metastases |
Den et al. [24] 2014 | 139 patients | Radical Prostatectomy and adjuvant radiation therapy | Biochemical recurrence and metastases | Area Under Curve of 78Â % and 80Â % in prediction of biochemical recurrence and metastases, respectively |
Ross et al. [23] 2014 | 85 patients | Radical Prostatectomy | Metastases after biochemical recurrence | Area Under Curve of 82Â % in prediction of metastases in patients that have developed Biochemical recurrence |
Cooperberg et al. [28] 2015 | 185 patients | Radical Prostatectomy | Disease free survival | Predict high risk for PCa death |
Den et al. [25] 2015 | 188 patients | Radical Prostatectomy and adjuvant radiotherapy in pT3 or positive margin patients | Metastases | Predict development of clinical metastases |
Klein et al. [27] 2014 | 162 patients | Radical Prostatectomy for high risk prostate cancer in node positive patients | Metastases within 5Â year after surgery | Predict development of metastases within 5Â years after surgery |
Alshalalfa et al. [21] 2015 | 463 patients | Radical Prostatectomy | Differences between patients that developed Biochemical recurrence or metastasis during follow up | Patients that develop metastases after BCR can be identified |