Parameter | Nobs | Npos | per | Hazard ratio (95 % CI) | P value |
---|---|---|---|---|---|
Univariable model | |||||
ACTa | |||||
AS-MQ | 3082 | 20 | 0.6 | 0.763 (0.392–1.484) | 0.425 |
DP | 3855 | 93 | 2.4 | 2.746 (1.773–4.253) | <0.001 |
AS-AQ: FDC | 2919 | 151 | 5.2 | 4.094 (2.540–6.600) | <0.001 |
AL | 8532 | 97 | 1.1 | Reference | |
Agea | |||||
< 1 year | 776 | 23 | 3.0 | 2.435 (1.268–4.676) | 0.008 |
1–4 years | 7772 | 236 | 3.0 | 2.780 (1.698–4.552) | <0.001 |
5–11 years | 4102 | 58 | 1.4 | 1.928 (1.225–3.035) | 0.005 |
12+ years | 5735 | 44 | 0.8 | Reference | |
Age (years) | 18385 | 361 | 2.0 | 0.965 (0.946–0.984) | <0.001 |
Derived haemoglobin (g/dL) | 14357 | 295 | 2.1 | 0.809 (0.758–0.862) | <0.001 |
Anaemia | |||||
Yes | 5505 | 183 | 3.3 | 1.824 (1.402–2.373) | <0.001 |
No | 8852 | 112 | 1.3 | Reference | |
Fever | |||||
Yes | 10569 | 173 | 1.6 | 0.594 (0.470–0.749) | <0.001 |
No | 7244 | 173 | 2.4 | Reference | |
Sex | |||||
Female | 8427 | 160 | 1.9 | 0.931 (0.754–1.149) | 0.505 |
Male | 9658 | 196 | 2.0 | Reference | |
Hyperparasitaemia | |||||
Yes | 1543 | 19 | 1.2 | 0.615 (0.384–0.984) | 0.043 |
No | 16845 | 342 | 2.0 | Reference | |
Log10 parasitaemia (/μL) | 18388 | 361 | 2.0 | 0.731 (0.619–0.864) | <0.001 |
Weight-for-age score | |||||
Underweightb | 8341 | 257 | 3.1 | 0.825 (0.744–0.915) | <0.001 |
Yes | 1418 | 80 | 5.6 | 1.768 (1.343–2.326) | <0.001 |
No | 6923 | 177 | 2.6 | Reference | |
Region | |||||
Asia | 3895 | 55 | 1.4 | 1.078 (0.356–3.263) | 0.894 |
South America | 615 | 8 | 1.3 | 0.482 (0.035–6.564) | 0.584 |
Africa | 13878 | 298 | 2.1 | Reference | |
TIAa | |||||
Low | 8406 | 64 | 0.8 | 0.371 (0.159–0.866) | 0.022 |
Moderate | 5120 | 129 | 2.5 | 0.746 (0.426–1.306) | 0.305 |
High | 4449 | 161 | 3.6 | Reference | |
Multivariable model | 14051 | 291 | 2.1 | ||
ACT: | |||||
AS-MQ | 0.566 ( 0.225–1.420) | 0.225 | |||
DP | 2.029 (1.240–3.317) | 0.005 | |||
AS-AQ: FDC | 4.014 (2.398–6.719) | <0.001 | |||
AL | Reference | ||||
Age | |||||
< 1 year | 1.707 ( 0.778–3.747) | 0.269 | |||
1–4 years | 2.303 (1.208–4.392) | 0.011 | |||
5–11 years | 1.418 (0.795–2.527) | 0.237 | |||
12+ years | Reference | ||||
Derived haemoglobin (g/dL) | 0.828 (0.774–0.886) | <0.001 | |||
Fever | 0.653 (0.503–0.848) | 0.001 | |||
Log10 parasitaemia (/μL) | 0.757 (0.624–0.917) | 0.004 |