Adverse event | Treatment group n (%) | Â | ||
---|---|---|---|---|
 | NRT | NRT+ | VR | P |
Cardiovascular (e.g., palpitations, tachycardia, chest pain) | 5 (2.0) | 3 (1.2) | 3 (1.2) | 0.687 |
Digestive (e.g., indigestion, nausea, diarrhea, constipation, flatulence) | 48 (19.6) | 64 (26.1) | 139 (56.3) | <0.001a |
Muscular (e.g., hypertonia, join, neck or jaw pain) | 7 (2.9) | 5 (2.0) | 4 (1.6) | 0.632 |
Nervous system (e.g., dizziness, light headedness, tingling fingers) | 24 (9.8) | 27 (11.0) | 31 (12.6) | 0.622 |
Psychiatric (e.g., anxious, disturbed concentration, suicidal ideation) | 12 (4.9) | 9 (3.7) | 18 (7.3) | 0.267 |
Sleep (e.g., abnormal dreams, insomnia, sleep disturbance) | 92 (37.6) | 115 (46.9) | 149 (60.3) | <0.001a |
Fatigue (e.g., drowsy, lethargic) | 9 (3.7) | 19 (7.8) | 43 (17.4) | <0.001a |
Metabolic (e.g., increased appetite, taste perversion) | 13 (5.3) | 14 (5.7) | 23 (9.3) | 0.151 |
Respiratory (e.g., coughing, congestion, shortness of breath) | 6 (2.4) | 9 (3.7) | 10 (4.0) | 0.592 |
Skin (e.g., rash, itchiness, dry skin, redness) | 94 (38.4) | 81 (33.1) | 12 (4.9) | <0.001a |
Other (e.g., eyes difficult to focus, hot flashes, low sex drive) | 21 (8.6) | 19 (7.8) | 48 (19.4) | <0.001a |