Fig. 1

Transcriptome changes associated with term gestation, RU486-, and lipopolysaccharide (LPS)-induced preterm labor (PTL) in the mouse myometrium. a Myometrium samples were collected from three mouse models of gestation: term labor (blue), progesterone withdrawal/RU486-induced PTL) (gray), and inflammatory/LPS-induced PTL (yellow). b Principal component analysis of transcriptome changes represented along principal component (PC)1 (30.7 % of total variance) and PC2 (23.3 % of total variance). Both term labor and RU486-induced PTL exhibit similar trajectories of transcriptome changes whereas animals experiencing LPS-induced PTL undergo a divergent trajectory. c–e Heatmaps representing hierarchical clustering analysis performed on differentially expressed genes (false discovery rate < 0.001) for unsupervised identification of gene expression patterns characterizing mouse myometrium collected from term labor (c), RU486-induced PTL (d), and LPS-induced PTL (e). The number of clusters was calculated using the Silhouettes algorithm. (n ≥ 4 mice for each experimental group). DMSO dimethyl sulfoxide, LAB active term labor, PBS phosphate-buffered saline