Fig. 4

Orthogonal signal correction-partial least squares (OSC-PLS) analysis illustrates gene expression changes associated with progression of term gestation and preterm labor (PTL) models. This OSC-PLS analysis describes correlations between time-associated gene changes characterizing term gestation (blue), RU486 (gray), and lipopolysaccharide (LPS) models (yellow). a Term gestation was used as training set and a positive correlation was found when using either RU486 or LPS models as test sets. b Using the RU486 model as a training set, a positive correlation was found with both term and LPS models. c When the LPS model was used as the training set, no significant correlation was found with either RU486 or term labor models. Correlation coefficients (r) were calculated using Pearson linear correlation (P < 0.05). DMSO dimethyl sulfoxide, LAB active term labor