Table 3 Available clinical studies on the effect of peptides on bone healing
From: The role of peptides in bone healing and regeneration: a systematic review
Study, Year | Peptide used | Clinical application | Result |
|---|---|---|---|
Yukna et al., 1998 [115] | P-15 | Periodontal osseous defects in 33 patients | • P-15 combined with anorganic bone matrix (ABM) yields better clinical results than freeze-dried bone allograft or open flap debridement |
Yukna et al., 2000 [114] | P-15 | Periodontal osseous defects in 33 patients | • P-15 combined with ABM yields better clinical results than the ABM alone |
Yukna et al., 2002 [122] | P-15 | Infra-bony periodontal defects in 25 patients | • Favourable 3-year results with P-15 combined with ABM suggest that it may have a beneficial effect long-term |
Yukna et al., 2002 [109] | P-15 | Periodontal regeneration case report | • Uneventful results with no evidence of root resorption, ankylosis or untoward inflammation |
Degidi et al., 2004 [128] | P-15 | Maxillary sinus augmentation in 7 patients | • Bone-replacement materials, without the addition of autologous bone, could be equally effective sinus augmentation |
Gelbart et al., 2005 [110] | P-15 | Sinus floor augmentation in 12 patients | • New trabecular bone is formed after grafting P-15 combined with ABM in the sinus floor |
Philippart et al., 2005 [130] | P-15 | Maxillary sinus floor grafting performed on 3 patients | • High degree of inorganic xenograft integration and natural bone regeneration |
Gomar et al. 2007 [236] | P-15 | Non-unions and delayed union in 22 patients | • Full consolidation was achieved in 90 % of the cases • Safe, economical and clinically useful alternative to autograft in the repair of un-united fractures |
Kasaj et al., 2008 [127] | P-15 | Infra-bony periodontal defects in 26 patients | • Significantly improved clinical outcomes compared to open flap debridement |
Butz et al., 2011 [116] | P-15 | Sinus floor augmentation in 24 patients | • All implants placed in the augmented sites integrated and were restored prosthetically |
Emam et al., 2011 [117] | P-15 | Sinus floor augmentation in 24 patients | • PepGen P-15 putty was found to be a promising osteoconductive graft for sinus augmentation, supporting immediate placement of implants |
Aspenberg et al., 2010 [33] | Teriparatide | Distal radial fractures in 27 patients | • The results must be interpreted with caution • Radiographic quality at an early time point might be a sensitive variable, perhaps better than time to cortical continuity • Teriparatide appeared to improve early callus formation in distal radial fractures |
Aspenberg et al., 2010 [28] | Teriparatide | Distal radial fractures in 102 patients | • Shortened time to healing for teriparatide group compared with placebo • These results should be interpreted with caution and warrant further study |
Chintamaneni et al., 2010 [34] | Teriparatide | Sternal fracture non-union | • Consolidation of fracture |
Oteo-Alvaro et al., 2010 [36] | Teriparatide | Humeral shaft non-union case report | • Consolidation of fracture |
Chrysalin trial [106] | Chrysalin | Distal radial fractures in 274 patients | • Statistically significant shorter time to the radiologic consolidation of the fractures but no differences in terms of the range of motion, grip strength and VAS or DASH scores |