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Fig. 1 | BMC Medicine

Fig. 1

From: Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease

Fig. 1

Malondialdehyde (MDA) epitopes in livers of patients with non-alcoholic steatohepatitis (NASH) and relationship between plasma immunoglobulin M (IgM) titers and non-alcoholic fatty liver disease (NAFLD). Immunohistochemical detection of MDA epitopes in liver sections (magnification 20×) of a a negative control and b two patients with NASH – arrows indicate localization of MDA2-positive staining in the liver tissue. Plasma IgM antibody titers against c MDA-low-density lipoprotein (LDL), d malondialdehyde-acetaldehyde (MAA)-LDL, e P1 mimotope, f CuOx-LDL, g PC-BSA, and h total IgM levels in patients with NAFLD and healthy controls. i Ratio of anti-P1 IgM titers to total IgM levels in patients with NAFLD and controls. Data are expressed in log10 relative light units (RLU)/100 ms. *p < 0.05, **p < 0.01, ***p < 0.001

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