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Table 1 Clinical and biological characteristics of patients with non-alcoholic steatohepatitis for antibody measurements

From: Low levels of IgM antibodies recognizing oxidation-specific epitopes are associated with human non-alcoholic fatty liver disease

 

Participant characteristics (mean ± SD)

 

Controls

(n = 68)

NAFLD

(simple steatosis) (n = 18)

NAFLD

(NASH) (n = 53)

Male/female

27/41

9/9

24/29

Age (y)

40.9 ± 12

45.7 ± 13

45.9 ± 10

BMI (kg/m2)

26.3 ± 4.9

33.6 ± 5.6

34.3 ± 4.7

Waist circumference (cm)

89.4 ± 13.7

108.5 ± 12.9

109.0 ± 14.3

Triglycerides (mg/dL)

  

Median

75

151

160

Interquartile range

48

66

118.5

Cholesterol (mg/dL)

181.33 ± 32.9

197.8 ± 53.2

196.2 ± 43.5

HDL (mg/dL)

54.8 ± 17.7

41.44 ± 8.0

42.87 ± 8.9

LDL (mg/dL)

105.65 ± 26.9

135.3 ± 47.2

122.9 ± 36.3

 

Markers of inflammation and liver blood tests (mean (IQR))

TNF-α (pg/ml)

2.5 (0.7)

3 (2.3)

3 (1.9)

MCP-1 (pg/ml)

96.9 (27)

122.4 (24.05)

120.1 (37.95)

IL-1β (pg/ml)

0.42 (0.87)

0.27 (0.36)

0.17 (0.64)

IL-6 (pg/ml)

13.2 (35.8)

16.1 (8.1)

24.5 (45.25)

IL-8 (pg/ml)

5.4 (4)

5.34 (3.5)

7.7 (8.05)

ÎłGT (IU/L)

-

51.6 (22.7)

55.6 (32)

Leptin

11.1 (8.8)

23.0 (15.8)

30.5 (18.5)

AST (IU/L)

21 (9)

28 (11.8)

49 (56.5)

ALT (IU/L)

18 (8)

38 (22.8)

66 (99.5)

AST/ALT ratio

1.3 (0.25)

0.8 (0.2)

0.8 (0.4)

  1. AST aspartate transaminase, ALT alanine transaminase, BMI body mass index, γGT gamma-glutamyltransferase, HDL high-density lipoprotein, IL interleukin, IQR interquartile range, LDL low-density lipoprotein, MCP-1 monocyte chemoattractant protein-1, NAFLD non-alcoholic fatty liver disease, NASH non-alcoholic steatohepatitis, TNF-α tumor necrosis factor alpha