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Table 3 The risks of cardiovascular disease related mortality by SF-36 vitality score in the EPIC-Norfolk study

From: Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study

Mortality SF-36 vitality score quartiles p-valuea
76–100 65–75 50–64 0–49  
Model A: unadjusted full dataset
HR (95 % CI)
1 (reference) 0.98 (0.84–1.15) 1.25 (1.07–1.46) 1.63 (1.40–1.89) <0.001
Model B: unadjusted with removal of baseline CVD/cancer
HR (95 % CI)
1 (reference) 0.92 (0.77–1.09) 1.18 (1.00–1.40) 1.41 (1.19–1.67) <0.001
Model C: confounders
HR (95 % CI)
1 (reference) 0.93 (0.78–1.12) 1.21 (1.00–1.45) 1.45 (1.18–1.78) <0.001
Model D: confounders + Hb
HR (95 % CI)
1(reference) 0.93 (0.77–1.13) 1.21 (1.00–1.48) 1.43 (1. 15–1.78) <0.001
Model E: confounders + TSH
HR (95 % CI)
1 (reference) 0.85 (0.68–1.05) 1.22 (0.98–1.52) 1.31 (1.03–1.68) 0.001
Model F: confounders + CRP
HR (95 % CI)
1 (reference) 0.96 (0.77–1.20) 1.16 (0.92–1.45) 1.38 (1.07–1.79) 0.021
Model G: confounders + Hb, CRP, TSH
HR (95 % CI)
1 (reference) 0.84 (0.64–1.09) 1.20 (0.92–1.56) 1.26 (0.93–1.70) 0.025
  1. aAcross quartiles
  2. Model A: unadjusted; Model B: unadjusted with removal of baseline CVD/cancer; Model C: Model B + statistically proven confounders – age, gender, body mass index, marital status, smoking, education, alcohol, social class, diet, physical activity, beta blocker, depression, pain, diabetes; Model D: Model C plus Hb adjusted; Model E: Model C plus TSH adjusted; Model F: Model C plus CRP adjusted; Model G: Model C plus Hb, CRP and TSH adjusted
  3. CI confidence interval, CRP C-reactive protein, CVD cardiovascular disease, Hb haemoglobin, HR hazard ratio, TSH thyroid-stimulting hormone