Fig. 2
From: Evaluation in alcohol use disorders – insights from the nalmefene experience
Number of patients enrolled in subgroup analyses in comparison with all patients randomised to nalmefene or placebo identified in a previous systematic review and meta-analysis [14]. Red square represents all randomised patients. Orange square represents all patients included in the three pivotal studies. Yellow square represents the population indicated for the use of nalmefene in the three pivotal studies. Light yellow square represents the population indicated for the use of nalmefene in the two 6-month pivotal studies. The subgroup analysis used for nalmefene approval was based on this population. * A publication [7] reports 667 patients whereas another publication [9] reports 641 patients for the two 6-month pivotal studies