Skip to main content

Table 5 Comparison of the baseline characteristics of the derivation and validation cohorts

From: Development and external validation of a faecal immunochemical test-based prediction model for colorectal cancer detection in symptomatic patients

Characteristics

Derivation cohort

(n = 1572)

Validation cohort

(n = 1481)

Significancea

Age (years)

68 (20–96)

64 (19–101)

<0.001

Sex (male)

810 (51.5 %)

719 (48.5 %)

0.1

Primary healthcare referral (yes)

360 (22.9 %)

570 (38.4 %)

<0.001

Symptoms

 • Change in bowel habit (yes)

899 (57.2 %)

778 (52.6 %)

0.01

 • Rectal bleeding (yes)

942 (59.9 %)

758 (51.2 %)

<0.001

Colonoscopy in the last 10 years (yes)

314 (20.0 %)

267 (18.0 %)

0.1

Continuous treatment with aspirin (yes)

224 (14.2 %)

261 (17.6 %)

0.01

Anorectal examination findings

 • Rectal mass (yes)

38 (2.4 %)

27 (1.8 %)

0.2

 • Benign anorectal lesion (yes)

646 (41.1 %)

491 (33.2 %)

<0.001

Laboratory results

 • Faecal haemoglobin (≥20 μg/g)

609 (38.7 %)

491 (33.1 %)

0.002

 • Blood haemoglobin (<10 g/dL)

75 (4.8 %)

91 (6.1 %)

0.1

 • Serum haemoglobin (10–12 g/dL)

251 (16.0 %)

239 (16.1 %)

0.1

 • CEA (≥3 ng/mL)

334 (21.2 %)

341 (23.0 %)

0.2

Bowel cleansing (adequate)b

1363 (86.7 %)

1274 (86.0 %)

0.7

Complete colonoscopy (yes)

1342 (85.4 %)

1389 (95.0 %)

<0.001

Normal colonoscopy (yes)

855 (38.1 %)

504 (34.0 %)

0.01

Colorectal cancer (yes)

214 (13.6 %)

136 (9.2 %)

<0.001

Significant colonic lesion (yes)c

463 (29.5 %)

389 (26.3 %)

0.05

 • Advanced adenoma (yes)

251 (16.0 %)

197 (13.3 %)

0.04

 • Polyposis (yes)

12 (0.8 %)

11 (0.7 %)

1

 • Non adenoma polyp >10 mm (yes)

6 (0.4 %)

26 (1.8 %)

<0.001

 • Colitis (yes)

36 (2.3 %)

67 (4.5 %)

0.001

  1. Qualitative variables are expressed as absolute numbers and percentages. Quantitative variables are expressed as median and range
  2. aDifferences between qualitative variables were analysed with Chi-square test. Differences between quantitative variables were analysed with Student’s t test. Differences with p < 0.05 are considered statistically significant
  3. bBowel cleansing was adequate if more than 90 % of the mucosa could be evaluated according to the Aronchick scale
  4. cColorectal cancer, advanced adenoma (≥10 mm, villous histology, high-grade dysplasia), polyposis (>10 polyps of any histology), colitis (any aetiology), polyps ≥10 mm, complicated diverticular disease, colonic ulcer and/or bleeding angiodysplasia
  5. CEA carcinoembryonic antigen