Table 6 Sensitivity and specificity for colorectal cancer and significant colonic lesion of the prediction models at the thresholds with 90 % (5.6) and 99 % (3.5) sensitivity for colorectal cancer detection in patients referred for colonoscopy from primary and secondary healthcare

≥5.6

Sensitivity^d

89.0 % (81.6–93.8)

88.9 % (83.9–92.6)

1

70.8 % (64.4–76.5)

64.1 % (59.6–68.4)

0.5

65.3 % (59.3–70.9)

60.2 % (55.9–64.3)

Specificity^d

75.8 % (72.6–78.8)

80.3 % (78.4–82.1)

0.01

80.8 % (77.5–83.7)

83.8 % (81.8–85.6)

1

81.6 % (78.2–84.5)

84.5 % (82.5–86.3)

≥3.5

Sensitivity^d

100 % (96.1–100.0)

99.6 % (97.2–100.0)

1

91.4 % (86.8–94.5)

87.8 % (84.4–90.5)

0.1

88.6 % (84.0–92.0)

86.1 % (82.8–88.9)

Specificity^d

44.1 % (40.6–47.7)

47.1 % (44.8–49.4)

0.1

48.8 % (45.0–52.8)

51.0 % (48.4–53.5)

0.6

50.1 % (46.0–54.1)

52.1 % (49.5–54.6)