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Table 1 Baseline characteristics of randomly assigned study participants

From: Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial

 

Testosterone group

(n = 49)

Placebo group

(n = 51)

P value

Age, years

54.3 (47.3–59.8)

52.8 (47.6–60.1)

0.93

Weight, kg

118.3 (15.7)

120.7 (19.6)

0.51

BMI, kg/m2

37.5 (34.9–40.5)

37.3 (34.7–41.6)

0.60

Waist circumference, cm

124 (118–131)

123 (117–136)

0.62

SBP, mmHg

135 (14)

130 (13)

0.06

DBP, mmHg

80 (78–88)

80 (78–85)

0.85

Handgrip, kg

44 (41–50)

46 (40–55)

0.65

Fat mass, kg

44.3 (10.0)

46.4 (10.6)

0.30

Fat mass, %

38.8 (33.5–42.3)

38.9 (36.0–43.5)

0.208

Lean mass, kg

68.1 (7.3)

67.4 (9.1)

0.67

ALM/height2, kg/m2

9.7 (1.0)

9.6 (0.8)

0.35

VAT area, mm2

25,088 (8617)

24,836 (9557)

0.89

Ischemic heart diseasea

6 (12.2 %)

6 (11.8 %)

0.94

Diabetes

10 (20.4 %)

12 (23.5 %)

0.71

Metformin

3 (6.1 %)

3 (5.9 %)

0.96

Statin use

14 (28.6 %)

15 (29.4 %)

1.0

Steps per day

6378 (4761–7543)

6371 (4816–7440)

0.79

Activity (%/day)

14.2 (5.7)

13.5 (4.5)

0.49

Physical performance test (sec)

36.2 (32.5–41.6)

37.1 (33.1–40.5)

0.40

TT, nmol/L, ECLIA

8.2 (2.5)

8.4 (2.3)

0.65

TT, nmol/L, LCMS/MS

6.8 (2.0)

7.0 (1.6)

0.55

cFT, pmol/L, ECLIA

195 (58)

208 (55)

0.23

cFT, pmol/L, LCMS/MS

159 (46)

172 (44)

0.15

SHBG, nmol/L

25 (18–31)

21 (17–26)

0.17

LH, IU/L

4.5 (3.3–5.6)

4.2 (3.1–5.2)

0.70

Fasting glucose, mmol/L

5.8 (5.3–6.1)

5.8 (5.4–6.4)

0.72

HOMA-IR

3.3 (1.0)

3.6 (1.1)

0.27

HbA1c, %

6.0 (5.6–6.2)

6.1 (5.8–6.5)

0.23

Total cholesterol, mmol/L

5.1 (4.3–5.6)

4.8 (4.4–5.7)

0.60

LDL-c, mmol/L

2.9 (0.9)

2.9 (1.0)

0.99

HDL-c, mmol/L

1.1 (1.0–1.3)

1.2 (1.0–1.3)

0.58

Triglycerides, mmol/L

1.9 (1.4–2.4)

1.7 (1.2–2.5)

0.38

Haematocrit

0.43 (0.02)

0.44 (0.02)

0.003

Haemoglobin, g/L

148 (8)

152 (9)

0.014

PSA, μg/L

0.7 (0.5–1.1)

0.7 (0.5–1.2)

0.79

  1. Data are mean (SD), median (IQR) based on normality testing, using the Kolmogorov–Smirnov test with Lilliefors correction, or number (%). P values were calculated for the difference between groups using t-test, Wilcoxon Signed Ranks Test, χ2 test, or Fisher exact test; P < 0.05 was considered significant
  2. aIschaemic heart disease denotes previous acute myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty
  3. BMI body mass index, DBP diastolic blood pressure, SBP systolic blood pressure, ALM appendicular lean mass, VAT visceral abdominal tissue, SHBG sex hormone binding globulin, TT testosterone, cFT calculated free testosterone, ECLIA electrochemiluminescence immunoassay, LCMS liquid chromatography-tandem mass spectroscopy, LH luteinising hormone, HbA1c glycated haemoglobin, LDL-c low density lipoprotein cholesterol, HDL-c high density lipoprotein cholesterol, PSA Prostate-specific antigen