Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

Table 2 Summary of enrichment analysis for the top 1494 differentially expressed genes between groups I, II (SVZ+) versus III, IV (SVZ–) (p < 0.05)

MetaCore^TM process network	Upregulated in SVZ+ (n = 771)	Downregulated in SVZ+ (n = 723)
Term	p value (n_upregulated/n_total)	p value (n_{downregulated}/n_total)
Blood vessel morphogenesis	0.669 (4/228)	1.55E-04 (16/228)
Regulation of epithelial-to-mesenchymal transition	0.943 (2/226)	4.57E-04 (15/226)
Leukocyte chemotaxis	0.985 (1/205)	5.32E-04 (14/205)
Chromatin modification	9.61E-04 (9/128)	0.392 (4/128)
T cell receptor signaling	0.971 (1/174)	1.22E-03 (12/174)
Cytoskeleton - actin filaments	0.465 (4/176)	1.35E-03 (12/176)
Notch signaling	0.507 (5/236)	2.08E-03 (14/236) 0.480 (4/144)
Skeletal muscle development	2.19E-03 (9/144)	2.08E-03 (14/236) 0.480 (4/144)
Cell cycle G1/S	0.407 (4/163)	2.31E-03 (11/163)
Inflammation - IL-2 signaling	0.878 (1/104)	4.11E-03 (8/104)

The top 10 enrichments according to p value are depicted (in bold: p < 0.01). In addition, the total number of genes per process network (n_total) as well as the intersect with significantly up- or downregulated genes are displayed (n_upregulated and n_{downregulated})

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