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Table 5 Clinical and molecular prognostic factors of overall (OS) and progression-free (PFS) survival in the validation cohort (n = 142 IDH wt patients) based on a univariate log-rank test and a multivariate Cox regression model

From: Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

 

OS

PFS

 

HR (95 % CI)

p value

HR (95 % CI)

p value

Univariate

     

 Clinico-pathological parameters

  Age at first diagnosis

1.05 (1.03–1.07)

4.0E-07

1.02 (1.00–1.04)

0.020

  Gender (male)

0.99 (0.70–1.41)

0.971

1.33 (0.87–2.04)

0.187

  Radiotherapy

0.29 (0.16–0.52)

9.7E-06

0.99 (0.31–3.13)

0.983

  Chemotherapy

0.41 (0.28–0.59)

1.4E-06

0.58 (0.37–0.91)

0.017

  Preoperative KPS

0.98 (0.97–0.99)

0.002

1.00 (0.99–1.01)

0.810

  MGMT methylation

0.83 (0.53–1.29)

0.401

1.15 (0.69–1.92)

0.588

  GTR

0.42 (0.28–0.62)

8.8E-06

0.78 (0.49–1.23)

0.286

  Location (SVZ+)

1.39 (0.99–1.96)

0.056

1.07 (0.71–1.61)

0.743

  Location (II vs. III)

1.19 (0.69–2.08)

0.526

1.30 (0.66–2.60)

0.445

 Candidate genes

     
 

Cut-offs

    

  IGFBP5

Q1

1.62 (1.09–2.39)

0.015

1.19 (0.73–1.94)

0.475

  DLL3

Median

1.61 (1.08–2.39)

0.017

1.64 (1.01–2.68)

0.043

  NTRK2

Q1

0.66 (0.44–1.00)

0.049

0.64 (0.39–1.07)

0.086

  PIR

Q1

0.62 (0.41–0.95)

0.025

0.66 (0.40–1.08)

0.092

  HES4

Q3

1.55 (1.03–2.32)

0.034

1.31 (0.81–2.13)

0.268

Multivariate

     

 Clinico-pathological parameters

  Age at first diagnosis

1.03 (1.00–1.06)

0.024

1.01 (0.99–1.04)

0.198

  Radiotherapy

0.22 (0.08–0.58)

0.002

  

  Chemotherapy

0.55 (0.29–1.05)

0.072

0.62 (0.36–1.06)

0.082

  Preoperative KPS

0.99 (0.98–1.01)

0.504

  

  GTR

0.48 (0.29–0.83)

0.007

  

  Location (SVZ+)

1.82 (1.09–3.04)

0.023

  

 Candidate genes

 

Cut-offs

    

  IGFBP5

Q1

0.82 (0.48–1.42)

0.488

  

  DLL3

Median

1.47 (0.83–2.60)

0.181

1.65 (1.00–2.70)

0.046

  NTRK2

Q1

0.75 (0.41–1.38)

0.358

  

  PIR

Q1

0.75 (0.41–1.36)

0.344

  

  HES4

Q3

2.03 (1.06–3.90)

0.033

  
  1. Gene expression data were dichotomized according to the median in “high” and “low” expression (“median cut-off”) and according to quartiles either in “top 25 % expression” and “<75 % expression” (“Q1 cut-off”) or “bottom 25 % expression” and “>25 % expression” (“Q3 cut-off”). p values < 0.05 are displayed in bold letters
  2. HR hazard ratio, CI confidence interval, KPS Karnofsky performance score, MGMT O6-methylguanine-DNA methytransferase, GTR gross total resection