From: How do you design randomised trials for smaller populations? A framework
 |  |  |  | Expected hypothetical | ||
---|---|---|---|---|---|---|
 |  |  |  | false positivesa | ||
Category | Disease | PMC | ct.gov | (PMC | ct.gov) | ||
 |  |  |  | 40 % | 10 % | 70 % |
Larger | Asthma | 216 | 110 | 4 | 2 | 1 | 1 | 6 | 3 |
Populations | Breast cancer | 632 | 897 | 13 | 18 | 3 | 4 | 19 | 27 |
 | Colorectal cancer | 470 | 122 | 9 | 2 | 2 | 1 | 14 | 4 |
 | Lung cancer | 380 | 149 | 8 | 3 | 2 | 1 | 11 | 4 |
Smaller | Muscular dystrophy | 9 | 11 | 0 | 0 | 0 | 0 | 0 | 0 |
Populations | Osteosarcoma | 8 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |