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Table 1 Patient age, gender, smoking status and measures of pulmonary function indices, CALIPER and visually scored CT parameters and echocardiography data in patients with connective tissue disease-related interstitial lung disease with a subanalysis for each of three separate groups derived following mathematical modelling using automated stratification

From: Evaluation of computer-based computer tomography stratification against outcome models in connective tissue disease-related interstitial lung disease: a patient outcome study

Variable

All CTD

Stratified Group 1

Stratified Group 2

Stratified Group 3

Units are percentage unless stated

(n = 203 unless stated)

(n = 15 unless stated)

(n = 138 unless stated)

(n = 50 unless stated)

Median age, years

58

58

59

53

Male/female

63/140

2/13

47/91

14/36

Survival (alive/dead)

131/72

14/1

95/43

22/28

Never/ex-smokers

122/76

9/6

83/52

30/18

Follow-up time, months

45.9 ± 24.0

57.8 ± 15.3

47.4 ± 22.2

38.1 ± 28.5

FEV1 % predicted

68.7 ± 18.4 (184)

79.5 ± 14.7 (14)

71.4 ± 18.3 (122)

58.7 ± 15.4 (48)

FVC % predicted

70.8 ± 20.9 (184)

88.3 ± 15.6 (14)

74.4 ± 20.7 (122)

56.7 ± 13.9 (48)

DLco % predicted

39.3 ± 14.2 (189)

54.5 ± 14.4 (14)

41.6 ± 13.0 (129)

28.4 ± 9.8 (46)

Kco % predicted

66.1 ± 17.6 (189)

72.2 ± 17.4 (14)

68.0 ± 16.8 (129)

58.9 ± 18.0 (46)

TLC % predicted

70.9 ± 16.7 (175)

89.6 ± 13.6 (13)

72.7 ± 16.0 (121)

59.4 ± 11.2 (41)

CPI

51.2 ± 13.7 (180)

35.8 ± 11.9 (14)

48.6 ± 12.6 (120)

62.7 ± 8.0 (46)

CALIPER ILD extent

20.2 ± 18.3

2.4 ± 2.1

12.7 ± 8.7

46.2 ± 15.0

CALIPER Fibrosis extent

5.5 ± 5.2

0.7 ± 0.5

4.0 ± 3.4

11.0 ± 5.9

CALIPER GGO

14.7 ± 15.7

1.7 ± 1.9

8.7 ± 7.8

35.2 ± 16.3

CALIPER Reticular pattern

4.9 ± 4.6

0.6 ± 0.4

3.7 ± 3.0

9.8 ± 5.3

CALIPER Honeycombing

0.6 ± 1.5

0.1 ± 0.1

0.4 ± 0.7

1.2 ± 2.8

CALIPER Emphysema

0.6 ± 2.8

0.1 ± 0.1

0.9 ± 3.3

0.2 ± 0.7

CALIPER PVV

4.2 ± 1.7

2.5 ± 0.5

3.6 ± 1.1

6.5 ± 1.3

CALIPER Normal lung

74.9 ± 19.5

95.1 ± 2.3

82.8 ± 9.5

47.1 ± 15.2

Visual ILD extent

53.5 ± 24.8

43.1 ± 28.4

47.4 ± 23.0

73.5 ± 17.0

Visual fibrosis extent

31.7 ± 19.9

7.2 ± 6.9

27.6 ± 16.4

50.6 ± 16.7

Visual GGO

20.7 ± 20.0

34.1 ± 28.8

18.9 ± 19.1

21.7 ± 17.9

Visual reticular pattern

27.6 ± 17.9

7.2 ± 6.9

24.9 ± 15.4

41.1 ± 17.7

Visual honeycombing

4.1 ± 9.3

0.0 ± 0.0

2.7 ± 6.6

9.4 ± 14.1

Visual consolidation

0.6 ± 2.3

1.8 ± 4.9

0.6 ± 2.2

0.4 ± 1.0

Visual emphysema

4.1 ± 10.7

5.0 ± 16.9

3.8 ± 9.8

4.8 ± 10.9

Visual mosaicism

1.7 ± 4.9

3.9 ± 8.1

1.4 ± 4.9

1.9 ± 3.6

Visual TxBx (max score 18)

5.5 ± 3.7

1.0 ± 1.2

5.1 ± 3.4

7.9 ± 3.6

Main PA diameter, mm

31.0 ± 4.8

28.7 ± 4.0

30.4 ± 4.3

33.3 ± 5.6

AAo diameter, mm

32.0 ± 4.0

31.9 ± 3.3

31.8 ± 4.0

32.7 ± 4.0

RVSP, mmHg

39.2 ± 16.1 (100)

28.9 ± 3.8 (7)

37.0 ± 14.7 (62)

45.8 ± 18.1 (31)

  1. Data represent mean values with standard deviations. CTD connective tissue disease, FEV1 forced expiratory volume in one second, FVC forced vital capacity, DLco diffusing capacity for carbon monoxide, Kco carbon monoxide transfer coefficient, TLC total lung capacity, CPI composite physiologic index, ILD interstitial lung disease, GGO ground glass opacity, PVV pulmonary vessel volume, TxBx traction bronchiectasis, PA pulmonary artery, AAo ascending aorta, RVSP right ventricular systolic pressure