From: Cumulative subgroup analysis to reduce waste in clinical research for individualised medicine
No. of trials sequentially included | No. of total patients involved | True positive | False positive | ||
---|---|---|---|---|---|
X1 | X2 | X3 | X4 | ||
1 | 800 | 9.8% | 4.8% | 5.4% | 5.2% |
2 | 1600 | 14.8% | 4.7% | 5.3% | 4.5% |
3 | 2400 | 19.7% | 5.1% | 5.5% | 5.0% |
4 | 3200 | 25.7% | 5.1% | 5.5% | 5.3% |
5 | 4000 | 30.7% | 4.9% | 5.4% | 4.6% |
6 | 4800 | 36.4% | 5.0% | 5.3% | 4.9% |
7 | 5600 | 41.3% | 5.4% | 5.5% | 4.6% |
8 | 6400 | 46.0% | 5.5% | 5.2% | 4.7% |
9 | 7200 | 50.7% | 5.5% | 5.4% | 4.5% |
10 | 8000 | 54.4% | 5.2% | 5.2% | 4.9% |
11 | 8800 | 58.3% | 5.5% | 5.3% | 4.9% |
12 | 9600 | 61.6% | 5.2% | 4.9% | 4.5% |
13 | 10,400 | 65.2% | 5.2% | 5.3% | 4.7% |
14 | 11,200 | 68.9% | 5.5% | 5.3% | 4.9% |
15 | 12,000 | 71.9% | 5.3% | 5.5% | 4.9% |
16 | 12,800 | 74.4% | 5.5% | 5.4% | 4.6% |
17 | 13,600 | 77.1% | 5.7% | 5.5% | 4.5% |
18 | 14,400 | 79.6% | 5.7% | 5.1% | 4.8% |
19 | 15,200 | 82.0% | 5.9% | 4.7% | 4.7% |
20 | 16,000 | 83.8% | 5.7% | 4.6% | 4.7% |