| Premenopausal | Perimenopausal | Naturally postmenopausal | Surgically postmenopausal |
---|---|---|---|---|
n = 39,397 | n = 8669 | n = 14,514 | n = 904 | |
Baseline | ||||
 Age, years | 36.9 ± 8.1 | 45.0 ± 8.1 | 55.3 ± 7.4 | 52.7 ± 8.1 |
 Age range, years | 18–60 | 18–62 | 18–65 | 21-65 |
 Current hormonal contraception use | 18,526 (47.6) | 1938 (22.7) | 1787 (12.6) | 825 (2.6) |
 Current smoker | 8125 (21.0) | 1969 (22.9) | 2751 (19.1) | 165 (18.4) |
 Antihypertensive medications | 1559 (4.0) | 608 (7.0) | 2356 (20.3) | 182 (20.3) |
 Lipid-lowering medications | 388 (1.0) | 178 (2.1) | 1222 (8.4) | 92 (10.2) |
 Ever HT use | 203 (0.5)a | 275 (3.2) | 1315 (9.1) | 253 (28.4) |
Outcome | ||||
 BMI, kg/m2 | 25.2 ± 4.6 | 26.0 ± 4.9 | 26.2 ± 4.5 | 27.3 ± 5.0 |
 SBP, mmHg | 119 ± 13 | 121 ± 14 | 125 ± 16 | 126 ± 16 |
 DBP, mmHg | 71 ± 9 | 72 ± 9 | 73 ± 9 | 72 ± 9 |
 TC, mmol/L | 4.7 ± 0.8 | 5.0 ± 0.9 | 5.6 ± 1.0 | 5.5 ± 1.0 |
 LDL-c, mmol/L | 2.9 ± 0.8 | 3.1 ± 0.8 | 3.6 ± 0.9 | 3.5 ± 0.9 |
 HDL-c, mmol/L | 1.6 ± 0.4 | 1.6 ± 0.4 | 1.7 ± 0.4 | 1.6 ± 0.4 |
 TG, mmol/L | 1.0 ± 0.5 | 1.0 ± 0.6 | 1.1 ± 0.6 | 1.2 ± 0.7 |
 Glucose, mmol/L | 4.8 ± 0.6 | 4.9 ± 0.7 | 5.0 ± 0.8 | 5.1 ± 1.0 |