Skip to main content

Table 2 Outcome measures at baseline and 6 months after surgery of patients receiving standard medical care (SMC), Supportive Intervention (SUPPORT) or Expectation Manipulation Intervention (EXPECT) (observed means)

From: Preoperative optimization of patient expectations improves long-term outcome in heart surgery patients: results of the randomized controlled PSY-HEART trial

 

(A) SMC

(B) SUPPORT

(C) EXPECT

Test statistic (F scores indicate interaction terms)

Significant pre–post comparisons

Disability (PDI)

 Baseline

22.78 (18.36–27.19)

22.14 (17.04–27.23)

25.89 (20.81–30.97)

F(2, 102.542) = 4.762;

B, C

 Follow-up

20.79 (15.35–26.23)

15.23 (10.82–19.65)

12.19 (8.50–15.89)

P = 0.011

Mental quality of life (SF-12)

 Baseline

48.96 (45.71–52.20)

51.60 (48.56–54.63)

47.98 (43.66–52.31)

F(2, 94.803) = 4.627;

C

 Follow-up

50.58 (47.02–54.14)

52.40 (48.83–55.97)

56.74 (54.29–59.19)

P = 0.012

Physical quality of life (SF-12)

 Baseline

40.26 (36.80–43.73)

39.55 (35.82–43.29)

37.15 (34.04–40.26)

F(2, 103.928) = 3.186;

B, C

 Follow-up

40.28 (36.58–43.98)

45.21 (41.23–49.19)

44.77 (41.13–48.41)

P = 0.045

Patient subjective working ability in hours per week follow-up

15.97 (10.50–21.43)

17.14 (10.45–23.80)

25.40 (19.90–30.90)

F(2, 74) = 3.325; P = 0.041a

ACa, BCa

Physical activity levels (IPAQ)

 Baseline

2668.40 (1919.56–3417.24)

2635.54 (1547.50–3723.57)

2433.63 (1249.51–3617.75)

F(2, 72.915) = 4.776;

B, C

 Follow-up

2957.64 (2128.50–3786.78)

5388.21 (3618.71–7157.71)

4700.60 (3470.76–5930.45)

P = 0.011

Cardiac anxiety (CAQ)

 Baseline (pre-intervention)

2.48 (2.29–2.67)

2.68 (2.47–2.90)

2.67 (2.44–2.89)

F(2, 107.021) = 3.980;

B, C

 Follow-up (after 6 months)

2.50 (2.31–2.69)

2.34 (2.11–2.57)

2.29 (2.11–2.47)

P = 0.022

Anxiety (HADS)

 Baseline (pre-intervention)

4.03 (3.07–4.98)

4.55 (3.42–5.67)

5.17 (3.47–6.86)

F(2,102.409) = 1.325;

 

 Follow-up (after 6 months)

3.24 (2.42–4.05)

2.52 (1.52–3.51)

3.61 (2.22–4.99)

P = 0.270

 

Depression (HADS)

 Baseline (pre-intervention)

4.59 (3.60–5.58)

4.00 (2.89–5.11)

5.11 (3.75–6.47)

F(2, 99.211) = 2.604;

 

 Follow-up (after 6 months)

3.68 (2.62–4.75)

1.88 (1.20–2.57)

2.58 (1.60–3.56)

P = 0.079

 

Outcome expectations (IPQ-E)

 Baseline (pre-intervention)

12.05 (11.49–12.62)

12.61 (12.10–13.12)

12.37 (11.90–12.83)

F(2, 98.882) = 0.084; P = 0.919

 

 Post psychological intervention

11.94 (11.32–12.56)

12.29 (11.97–12.60)

12.09 (11.52–12.66)

 

Expected personal control (IPQ-E)

 Baseline (pre-intervention)

15.28 (14.74–15.81)

15.24 (14.55–15.92)

14.03 (12.90–15.16)

F(2, 103.971) = 8.748; P < 0.001

C

 Post psychological intervention

15.16 (14.43–15.88)

14.91 (14.13–15.68)

16.06 (15.40–16.73)

Patients rehospitalized after CABG, n (%)a

 Follow-up

9 (26.47)

7 (23.33)

3 (9.38)

χ 2 (2) = 3.380; P = 0.185

 

LVEF, n (%) at follow-up

  ≥ 50

25 (80.6)

23 (88.5)

24 (100)

χ 2 (2) = 5.138; P = 0.077

 

 49–30

6 (19.4)

3 (11.5)

0 (0)

  < 30

0 (0)

0 (0)

0 (0)

Interleukin-6 (pg/mL)a

 Baseline (pre-intervention)

3.71 (2.14–5.27)

2.10 (1.34–2.86)

3.58 (1.91–5.25)

F = (6, 216.924) =2.523; P = 0.022

Follow-up: AC

 Post psychological intervention

3.06 (2.03–4.10)

1.83 (1.44–2.22)

3.44 (2.07–4.82)

 After surgery

24.75 (18.61–30.89)

19.56 (13.63–25.49)

19.90 (15.63–24.18)

 Follow-up (after 6 months)

4.83 (2.99–6.68)

3.66 (2.16–5.16)

2.39 (1.38–3.41)

Interleukin-8 (pg/mL)

 Baseline (pre-intervention)

5.48 (4.05–6.90)

5.56 (4.33–6.79)

5.78 (4.18–7.38)

F = (6, 206.632) = 4.186; P = 0.001

Post-surgery: AB, AC

 Post psychological intervention

4.76 (3.86–5.66)

5.13 (3.89–6.38)

5.52 (3.73–7.30)

 After surgery

13.71 (11.44–15.97)

10.31 (8.14–12.48)

11.02 (8.64–13.40)

 Follow-up (after 6 months)

5.08 (3.63–6.52)

4.83 (4.22–5.45)

6.07 (4.76–7.37)

Tumor necrosis factor alpha (pg/mL)a

 Baseline (pre-intervention)

2.01 (1.60–2.42)

1.48 (1.19–1.76)

1.61 (1.39–1.83)

F(6, 174.813) = 1.404; P = 0.216

 

 Post psychological intervention

2.20 (1.78–2.62)

1.54 (1.32–1.76)

1.72 (1.43–2.01)

 After surgery

3.63 (2.72–4.54)

2.17 (1.81–2.52)

3.12 (2.51–3.72)

 Follow-up (after 6 months)

2.66 (2.00–3.32)

1.72 (1.48–1.96)

2.09 (1.70–2.49)

C-reactive protein (μg/mL)a

 Baseline (pre-intervention)

2.49 (1.84–3.15)

2.23 (1.32–3.15)

2.96 (2.00–3.92)

F(6, 209.520) = 1.410; P = 0.212

 

 Post psychological intervention

2.22 (1.62–2.81)

2.19 (1.52–2.86)

3.42 (2.07–4.76)

 After surgery

123.93 (94.24–153.62)

101.71 (77.65–125.76)

96.14 (76.91–115.38)

 Follow-up (after 6 months)

4.23 (2.05–6.42)

4.17 (1.96–6.38)

2.33 (1.54–3.12)

  1. For significant group × time interactions follow-up tests were calculated. ‘Significant pre–post comparisons’ (last column) means that the baseline value was significantly different from the post value for the groups stated in this column (e.g., ‘B, C’ would indicate that for SUPPORT and EXPECT the baseline values were significantly different from the post values within both groups, but for SMC baseline and post values did not differ significantly). For variables only reported at follow-up (e.g., working ability) and for biological variables (four assessment points), the letters indicate significant group differences at the indicated time point. (e.g. ‘Follow-up: AC’ would indicate that groups SMC and EXPECT have significantly different scores at follow-up)
  2. aBecause this variable was only assessed at follow-up, the column “test statistics” includes group comparison (three groups), while the column “pre–post comparison” includes pairwise comparisons
  3. PDI Pain Disability Index, SF-12 Short-Form Health Survey, IPAQ International Physical Activity Questionnaire, CAQ Cardiac Anxiety Questionnaire, HADS Hamilton Anxiety and Depression Scale, IPQ-E Expected Illness Perception Questionnaire, CABG coronary artery bypass graft, LVEF left ventricular ejection fraction