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Table 3 SNPs found to be significantly associated with AMY1 or AMY2 plasma enzymatic activity in D.E.S.I.R. participants, with a replication study in ABOS participants

From: Relationship between salivary/pancreatic amylase and body mass index: a systems biology approach

 

SNP ID

Chr: position (Build 37)

Closest gene

Tested allele/Other allele

Cohort study

n

MAF

Effect size ± SE per allele

P value

AMY1

rs10492100

12:11085820

PRH1-PRR4

C / T

Discovery

3673

0.21

−2.36 ± 0.39

6.6 × 10−10

Replication

488

0.25

−2.31 ± 0.85

6.9 × 10−3

Meta-analysis

4227

−2.35 ± 0.35

3.3 × 10−11

AMY2

rs12075225

1:104115017

AMY2B

A / C

Discovery

3905

0.10

5.11 ± 0.29

3.3 × 10−70

Replication

488

0.07

3.48 ± 1.04

9.1 × 10−4

Meta-analysis

4227

4.99 ± 0.28

2.0 × 10−71

AMY2

rs507666

9:136149399

ABO

A / G

Discovery

3905

0.22

−1.17 ± 0.22

5.7 × 10−8

Replication

488

0.21

−1.21 ± 0.60

4.4 × 10−2

Meta-analysis

4227

−1.17 ± 0.21

1.3 × 10−8

  1. AMY1 salivary amylase, AMY2 pancreatic amylase, Chr chromosome, MAF minor allele frequency, SE standard error