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Table 2 Significantly enriched KEGG pathways among differentially methylated genes between myoblasts and myotubes

From: Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects

Pathway (total number of genes in pathway)

Observed/Expected number of genes

P value

q value

Non-obese subjects

 Pathways in cancer (325)

321/295

9.8 × 10−10

2.2 × 10−7

 Metabolic pathways (1112)

1060/1009

3.3 × 10−9

3.7 × 10−7

 Focal adhesion (200)

199/182

7.6 × 10−8

4.3 × 10−6

 Endocytosis (200)

199/182

7.6 × 10−8

4.3 × 10−6

 MAPK signaling pathway (267)

260/242

1.4 × 10−5

5.0 × 10−4

 Ubiquitin mediated proteolysis (134)

133/122

3.3 × 10−5

1.1 × 10−3

 Neurotrophin signaling pathway (127)

126/115

6.2 × 10−5

1.8 × 10−3

 Protein processing in endoplasmic reticulum (165)

162/150

1.0 × 10−4

1.8 × 10−3

 Lysosome (121)

120/110

1.0 × 10−4

1.8 × 10−3

 Cell cycle (124)

123/113

8.1 × 10−5

1.8 × 10−3

 Oxidative phosphorylation (119)

118/108

1.0 × 10−4

1.8 × 10−3

 Regulation of actin cytoskeleton (211)

205/192

2.0 × 10−4

2.9 × 10−3

 TGF-beta signaling pathway (84)

84/76

3.0 × 10−4

3.8 × 10−3

 Axon guidance (129)

127/117

4.0 × 10−4

4.8 × 10−3

 Phosphatidylinositol signaling system (78)

78/71

5.0 × 10−4

5.7 × 10−3

 Purine metabolism (162)

158/147

6.0 × 10−4

6.5 × 10−3

 Calcium signaling pathway (176)

171/160

8.0 × 10−4

7.9 × 10−3

 Pyrimidine metabolism (98)

97/89

8.0 × 10−4

7.9 × 10−3

 Adipocytokine signaling pathway (68)

68/62

1.4 × 10−3

1.3 × 10−2

 p53 signaling pathway (68)

68/62

1.4 × 10−3

1.3 × 10−2

 Wnt signaling pathway (149)

145/135

1.5 × 10−3

1.3 × 10−2

 ErbB signaling pathway (87)

86/79

2.1 × 10−3

1.7 × 10−2

 Melanogenesis (101)

99/92

3.5 × 10−3

2.6 × 10−2

 Inositol phosphate metabolism (57)

57/52

4.0 × 10−3

2.9 × 10−2

 Peroxisome (79)

78/72

4.3 × 10−3

3.0 × 10−2

 mTOR signaling pathway (52)

52/47

6.5 × 10−3

4.2 × 10−2

 Spliceosome (127)

123/115

7.0 × 10−3

4.4 × 10−2

Obese subjects

 Pathways in cancer (325)

325/311

4.3 × 10−7

9.8 × 10−5

 Metabolic pathways (1112)

1086/1063

2.0 × 10−4

2.3 × 10−2