Skip to main content

Table 3 Methylome-CpGs associated with birth weight at a false discovery rate of 0.05

From: Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome

CpG

CHR

POS

IQR

Est

95% CI

P

Gene

Annotation

cg00510507

10

61900413

8.4

4.9

(3.5 to 6.2)

4.6 × 10–8

ANK3

5’ UTR

cg08390209

9

22005563

6.6

7.1

(5.1 to 9.0)

4.9 × 10–8

CDKN2B

3’ UTR

cg23671997

15

65677753

4.6

9.2

(6.5 to 12)

1.6 × 10–7

IGDCC4

Intron

cg14300531

11

73969506

9.6

–3.9

(–5.0 to –2.8)

4.0 × 10–7

P4HA3

Intron

cg25685359

22

46473721

8.8

–3.7

(–4.8 to –2.6)

9.9 × 10–7

MIRLET7BHG

Non-coding

cg22383874

17

48670670

4.8

7.6

(5.2 to 10)

1.2 × 10–6

CACNA1G

Intron

cg02729344

16

49888237

6.6

6.8

(4.7 to 9.0)

1.9 × 10–6

ZNF423

Intron

cg25487405

22

46473039

5.5

–5.6

(–7.2 to –3.9)

2.2 × 10–6

MIRLET7BHG

Non-coding

  1. Eight CpGs were significantly associated with birth weight at a false discovery rate (FDR) of 0.05. The eight CpGs mapped to seven loci (two CpGs mapped to MIRLET7BHG). Regression coefficients (Est), 95% confidence intervals (CI) and P values are reported as percentage change in birth weight for 10% increase in percent methylation. Interquartile range (IQR), chromosome (CHR) and position (POS) of CpG are also shown. Analysis was done by linear regression of log-transformed birth weight against methylation at each CpG site, adjusted for child sex, gestational age, ethnicity, cellular proportions and interactions between ethnicity and cellular proportions