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Table 4 Impact of neoadjuvant chemotherapy on pancreatic adenocarcinoma (PA)

From: Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients

Metabolite

Neoadjuvant chemotherapy

Mean (nmol/mg)

p value

Ascorbate

No

0.3988 ± 0.2221

0.6648

Yes

0.4062 ± 0.2227

Aspartic acid

No

0.6229 ± 0.2255

0.0017

Yes

0.9658 ± 0.6074

Choline

No

0.8849 ± 0.3887

0.6600

Yes

0.9539 ± 0.4702

Creatine

No

1.3561 ± 0.5057

0.4285

Yes

1.4464 ± 0.5971

Ethanolamine

No

0.6148 ± 0.2620

0.1958

Yes

0.7511 ± 0.4177

Glutamate

No

2.4650 ± 0.7699

0.0908

Yes

2.8070 ± 0.9767

Glycerol

No

2.7550 ± 1.1994

0.1339

Yes

3.5300 ± 2.6914

Glycine

No

2.2663 ± 0.8577

0.1265

Yes

2.9025 ± 1.8798

Glycerophosphocholine

No

1.0319 ± 0.5029

0.7421

Yes

1.0810 ± 0.7982

Lactate

No

16.1370 ± 4.7272

0.7969

Yes

15.9030 ± 5.3324

Phosphorylcholine

No

0.9764 ± 0.5008

0.9092

Yes

0.9518 ± 0.4822

Taurine

No

4.4630 ± 1.4062

0.8886

Yes

4.3490 ± 1.3425

Threonine

No

1.1931 ± 0.4229

0.6273

Yes

1.2957 ± 0.6961

Glutamine

No

0.6394 ± 0.2272

0.5864

Yes

0.6870 ± 0.2668

Succinic acid

No

0.1762 ± 0.0763

0.4400

Yes

0.1866 ± 0.0739

Glucose

No

1.3141 ± 1.1020

0.0813

Yes

2.3227 ± 2.7375

Tyrosine

No

0.0730 ± 0.0493

0.3140

Yes

0.1097 ± 0.1479

Phenylalanine

No

0.1789 ± 0.0811

0.1622

Yes

0.1097 ± 0.1958

  1. Results of the Mann-Whitney U test. Metabolite differences between PA without neoadjuvant chemotherapy and PA with neoadjuvant chemotherapy (univariate analysis, nonparametric test)