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Table 5 Metabolite differences according to survival rate

From: Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients

Metabolite

No neoadjuvant chemotherapy

Mean (nmol/mg)

p value

Ascorbate

LongSurv

0.3988 ± 0.2221

0.5414

ShortSurv

0.4062 ± 0.2227

Aspartic acid

LongSurv

0.6229 ± 0.2255

0.7430

ShortSurv

0.9658 ± 0.6074

Choline

LongSurv

0.8849 ± 0.3887

0.0150

ShortSurv

0.9539 ± 0.4702

Creatine

LongSurv

1.3561 ± 0.5057

0.2766

ShortSurv

1.4464 ± 0.5971

Ethanolamine

LongSurv

0.6148 ± 0.2620

0.0078

ShortSurv

0.7511 ± 0.4177

Glutamate

LongSurv

2.4650 ± 0.7699

0.2766

ShortSurv

2.8070 ± 0.9767

Glycerol

LongSurv

2.7550 ± 1.1994

0.6730

ShortSurv

3.5300 ± 2.6914

Glycine

LongSurv

2.2663 ± 0.8577

0.2359

ShortSurv

2.9025 ± 1.8798

Glycerophosphocholine

LongSurv

1.0319 ± 0.5029

0.7430

ShortSurv

1.0810 ± 0.7982

Lactate

LongSurv

16.1370 ± 4.7272

0.0360

ShortSurv

15.9030 ± 5.3324

Phosphorylcholine

LongSurv

0.9764 ± 0.5008

0.6730

ShortSurv

0.9518 ± 0.4822

Taurine

LongSurv

4.4630 ± 1.4062

0.4807

ShortSurv

4.3490 ± 1.3425

Threonine

LongSurv

1.1931 ± 0.4229

0.3213

ShortSurv

1.2957 ± 0.6961

Glutamine

LongSurv

0.6394 ± 0.2272

0.1672

ShortSurv

0.6870 ± 0.2668

Succinic acid

LongSurv

0.1762 ± 0.0763

0.0747

ShortSurv

0.1866 ± 0.0739

Glucose

LongSurv

1.3141 ± 1.1020

0.4807

ShortSurv

2.3227 ± 2.7375

Tyrosine

LongSurv

0.0730 ± 0.0493

0.0592

ShortSurv

0.1097 ± 0.1479

Phenylalanine

LongSurv

0.1789 ± 0.0811

0.0055

ShortSurv

0.1097 ± 0.1958

  1. Results of the Mann-Whitney U test (univariate analysis, nonparametric test). No neoadjuvant chemotherapy. LongSurv long-term survivors, ShortSurv short-term survivors