Table 2 Diagnostic yield of tuberculosis cases from different sample types and the proportion of each diagnosed by Determine TB-LAM
| Â | Â | Â | Proportion diagnosed by Determine TB-LAM (true positives) | |
|---|---|---|---|---|
Samples from which TB diagnoses were made | Number of TB diagnoses | Diagnostic yield, % (95% CI) | Number | Proportion, % (95% CI) |
All clinical samples and tests | 139 | 100 | 53 | 38.1 (30.0–46.7) |
Study samples collected during the first 24Â h of admission | ||||
 Urine | ||||
 Urine Xpert (unconcentrated) | 59 | 42.4 (34.1–51.1) | 37 | 62.7 (49.1–75.0) |
 Urine Xpert (concentrated) | 82 | 59.0 (50.3–67.3) | 43 | 52.4 (41.1–63.6) |
Sputum | ||||
 Smear microscopy | 27 | 19.4 (13.2–27.0) | 15 | 55.6 (35.3–74.5) |
 Xpert (1st sample only) | 37 | 26.6 (19.5–34.8) | 17 | 45.9 (29.5–63.1) |
 Xpert (either sample) | 39 | 28.1 (20.8–36.3) | 17 | 43.6 (27.8–60.4) |
All study samples collected during any point during admission | ||||
 All EPTB cases* | 113 | 81.3 (73.8–87.4) | 51 | 45.1 (35.8–54.8) |
 Blood | 41 | 29.5 (22.1–37.8) | 27 | 65.9 (49.4–79.9) |
 Pleural fluid | 13 | 9.4 (5.1–15.5) | 4 | 30.8 (9.0–61.4) |
 Urinea | 92 | 66.2 (57.9–74.0) | 46 | 50.0 (39.4–60.6) |
 Cerebrospinal fluid | 8 | 5.8 (2.5–11.0) | 1 | 12.5 (0.3–52.7) |
 Lymph node fine needle aspirate | 6 | 4.3 (1.6–9.2) | 4 | 66.7 (22.3–95.7) |